fMRI Guided TMS Enhancement of Associative Memory Networks
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Epilepsy |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 12/26/2018 |
| Start Date: | October 14, 2016 |
| End Date: | September 30, 2017 |
A Randomized Controlled Pilot Study of TMS Enhancement of Associative Memory Networks in Healthy Subjects and Epilepsy Patients
This is a randomized, single-blinded, controlled phase 1 study to demonstrate feasibility and
explore the neurophysiologic and clinical effects of repetitive transcranial magnetic
stimulation (TMS) interventions in epilepsy patients and healthy controls. The inclusion of a
control group will be used to see whether epilepsy patients, who suffer from a higher degree
of comorbid memory difficulty presumably from entorhinal-hippocampal dysfunction, can benefit
from a TMS intervention can benefit as much as a healthy matched population. Investigators
will also be looking at functional connectivity between the hippocampus and cortical regions
explore the neurophysiologic and clinical effects of repetitive transcranial magnetic
stimulation (TMS) interventions in epilepsy patients and healthy controls. The inclusion of a
control group will be used to see whether epilepsy patients, who suffer from a higher degree
of comorbid memory difficulty presumably from entorhinal-hippocampal dysfunction, can benefit
from a TMS intervention can benefit as much as a healthy matched population. Investigators
will also be looking at functional connectivity between the hippocampus and cortical regions
Inclusion Criteria:
- Fluent in English
- Right-handed
- Score at least 26 out of 30 on the Montreal Cognitive Assessment (MOCA). Healthy
subjects will be matched to age, handedness, and education compared to epilepsy
subjects.
- Must be able to provide informed consent.
Exclusion Criteria:
- Any history of a neurological disorder
- Chronic or progressive medical condition
- Any history of severe traumatic brain injury or skull defect
- Metal or devices in the head, including neurostimulators of metal foreign bodies
- Any other implanted metal device, including pacemaker, spinal cord stimulator, VNS.
- Any other ferromagnetic substance in the body (including tattoos, dental prosthetics,
etc).
- Taking a medication which may lower the seizure threshold within the 4 weeks prior to
the start of the study, including use of neuroleptic (esp. clozapine), antibiotic
(penicillin, cephalosporins), and bronchodilating medications.
- Pregnancy
We found this trial at
1
site
550 1st Ave
New York, New York 10016
New York, New York 10016
(212) 263-7300
Principal Investigator: Anli Liu, MD
New York University School of Medicine NYU School of Medicine has a proud history that...
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