fMRI in Impulsivity

Inclusion criteria:

- Healthy Controls: Volunteers (age 18-50 yrs) in generally good Psychiatric and
non-Psychiatric medical health

- Borderline Personality Disorder subjects: Research volunteers (age 18-50 yrs) who meet
DSM-5 criteria for Borderline Personality Disorder

Exclusion criteria:

All Participants:

- Current medications which affect the central nervous system or vascular activity, such
as anti-depressants, anxiolytics, or blood-pressure medications

- Positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines

- Positive breathalyzer test for alcohol

- History of clinically significant neurologic disorders or head trauma with loss of
consciousness greater than 30 minutes

- Clinically significant non-psychiatric medical disorder requiring ongoing treatment.

- Unwillingness or inability to sign a written informed consent form

- Pregnancy as assessed by a urine test for ß-HCG at each visit

- Medical or physical contraindications for participation based on medical history
interview, labs, and physical exam

- Metal fragments or other bodily metal (e.g., pacemaker, orthopedic
prosthesis),claustrophobia, or any other condition that would put the subjects at risk
for MRI scanning

In addition, Healthy Controls excluded, if:

- DSM-5 diagnoses of Personality Disorders (based on SCID-II)

- DSM-5 diagnoses based on the SCID-I (including the eating disorders module)

- History of arrest or incarceration

In addition, Borderline Personality Disorder Subjects excluded if:

- DSM-5 diagnoses

- DSM-5 Personality Disorder other than Cluster B Personality disorders

- Current psychoactive medications

- Further exclusion criteria apply