Serial Phlebotomy in Voluntary Blood Donors
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - 70 |
| Updated: | 5/6/2016 |
| Start Date: | June 2009 |
| End Date: | August 2012 |
Blood donation has been proposed to be associated with reduced risk of cardiovascular
disease, but the effects of phlebotomy on vascular function in human subjects have not been
well characterized. A prospective randomized double-blind study was undertaken to determine
the effects of iron loss and red blood cell loss induced by serial phlebotomy on vascular
endothelial function in the brachial artery.
disease, but the effects of phlebotomy on vascular function in human subjects have not been
well characterized. A prospective randomized double-blind study was undertaken to determine
the effects of iron loss and red blood cell loss induced by serial phlebotomy on vascular
endothelial function in the brachial artery.
84 Fe-replete, non-anemic subjects were randomly assigned to one of three experimental
serial phlebotomy procedures designed to induce Fe loss or RBC loss. Brachial artery
reactivity (BAR, %) in response to transient oxidative stress induced by oral methionine was
measured with high-resolution duplex ultrasound imaging before and after study phlebotomy
procedures.
serial phlebotomy procedures designed to induce Fe loss or RBC loss. Brachial artery
reactivity (BAR, %) in response to transient oxidative stress induced by oral methionine was
measured with high-resolution duplex ultrasound imaging before and after study phlebotomy
procedures.
Inclusion Criteria:
- hemoglobin levels >13.5 g/dl for men, or >12.5 g/dl for women
- serum ferritin 50-400 ng/ml
Exclusion Criteria:
- known intolerance of phlebotomy procedures
- major trauma or surgical procedures in the last 2 years
- menstrual or other uterine bleeding in the last 2 years
- chronic oral anticoagulation or dual antiplatelet therapy
- chronic non-steroidal anti-inflammatory drug use
- known history of hemochromatosis or other disorder of hematopoiesis or Fe metabolism
- chronic oral Fe supplementation other than Fe-containing multivitamins
- history of active cancer in the past 2 years
- known history of chronic inflammatory disease
- uncontrolled hypertension
- electrocardiographic evidence of prior myocardial infarction
- diabetes mellitus
- fasting glucose >100 mg/dL
- body mass index >40 kg/m2
- any tobacco use in the past 6 months
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