Acute Kidney Injury in Critically Ill Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 8/31/2018 |
| Start Date: | July 2016 |
| End Date: | May 2019 |
| Contact: | Patricia Moore, CCRP |
| Email: | pamoore@llu.edu |
| Phone: | 909-558-8493 |
Predicting Acute Kidney Injury in Critically Ill Trauma Patients Using Metalloproteinase 2 (TIMP2) and Insulin-like Growth Factor Binding Protein7 (IGFBP 7)
Acute kidney injury (AKI) in critically ill trauma patients has been shown to significantly
increase mortality, length of stay, and costs, however detection has proven difficult as
markers like elevated creatinine and decreased urine output may take days to manifest and are
late indicators of AKI. The combination of two urinary biomarkers, Tissue Inhibitor of
Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7), has
been shown to increase within 12 hours following renal insult, allowing assessment of risk
for developing acute kidney injury. Therefore, the investigators plan to assess if acute
kidney injury in critically ill trauma patients can be determined earlier using urinary
TIMP-2 and IGFBP-7 via the NephroCheck testing system. These markers have not been
specifically evaluated in trauma patients at risk of AKI.
increase mortality, length of stay, and costs, however detection has proven difficult as
markers like elevated creatinine and decreased urine output may take days to manifest and are
late indicators of AKI. The combination of two urinary biomarkers, Tissue Inhibitor of
Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7), has
been shown to increase within 12 hours following renal insult, allowing assessment of risk
for developing acute kidney injury. Therefore, the investigators plan to assess if acute
kidney injury in critically ill trauma patients can be determined earlier using urinary
TIMP-2 and IGFBP-7 via the NephroCheck testing system. These markers have not been
specifically evaluated in trauma patients at risk of AKI.
Inclusion Criteria:
- trauma patients with multiple injuries;
- abdominal injuries;
- crush injuries;
- those who present in shock (systolic blood pressure <90 or mean arterial pressure
<65);
- require blood transfusions, vasopressors or mechanical ventilation
Exclusion Criteria:
- known pregnancy;
- patients under 21 years of age;
- known moderate to severe AKI prior to enrollment and end stage renal disease. known
moderate to severe AKI prior to enrollment and end stage renal disease
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