A Comparison of the Effects on Cardiovascular Risk Factors of Korean and American Dietary Profiles



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:25 - 65
Updated:5/12/2016
Start Date:January 2012
End Date:May 2012

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The primary aim of this study is to compare, in a group of at-risk individuals, the role of
three dietary patterns on indices of Cardiovascular Disease (CVD) risk: a) the recommended
Korean pattern; b) the typical American diet, based on national dietary intake surveys; and
c) the 2010 DGA diet pattern. A secondary aim will be to assess the effects of each diet on
intestinal microbiota and on inflammatory biomarkers.


Inclusion Criteria:

- Non Asian-American men and women between the ages of 25-65 years

- Body Mass Index (BMI) ≥ 25 and ≤ 38 kg/m2

- Fasting LDL-cholesterol ≥ 130 mg/dL

- Willingness and ability to make scheduled appointments at clinical site as required
by study protocol

Exclusion Criteria:

- Major aversions to Korean foods

- Known food allergies that would interfere with study protocol

- Use of cholesterol-lowering medication or dietary supplements

- Use of blood pressure medications

- Use of prebiotics or probiotics in the last 3 months

- Received medication for bacterial infection (antibiotic) in the last 3 months

- Regular use of fiber supplements or laxatives

- Conditions requiring ongoing medical care and/or medication, including kidney, liver,
gastrointestinal or endocrine disorders.

- Regular tobacco use within 6 months prior to the start of the study

- History of eating disorders or other dietary patterns which are not consistent with
the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)

- Voluntary or involuntary weight loss of 10% of body weight within the last 12 months

- Self-report of alcohol or substance abuse within the past 12 months

- Donated blood during the 8 week period prior to the study

- Other medical, psychiatric, or behavioral factors that in the judgment of the
Principal Investigator may interfere with study anticipation or the ability to follow
the intervention protocol
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