A Comparison of the Effects on Cardiovascular Risk Factors of Korean and American Dietary Profiles
Status: | Completed |
---|---|
Conditions: | High Cholesterol |
Therapuetic Areas: | Cardiology / Vascular Diseases |
Healthy: | No |
Age Range: | 25 - 65 |
Updated: | 5/12/2016 |
Start Date: | January 2012 |
End Date: | May 2012 |
The primary aim of this study is to compare, in a group of at-risk individuals, the role of
three dietary patterns on indices of Cardiovascular Disease (CVD) risk: a) the recommended
Korean pattern; b) the typical American diet, based on national dietary intake surveys; and
c) the 2010 DGA diet pattern. A secondary aim will be to assess the effects of each diet on
intestinal microbiota and on inflammatory biomarkers.
three dietary patterns on indices of Cardiovascular Disease (CVD) risk: a) the recommended
Korean pattern; b) the typical American diet, based on national dietary intake surveys; and
c) the 2010 DGA diet pattern. A secondary aim will be to assess the effects of each diet on
intestinal microbiota and on inflammatory biomarkers.
Inclusion Criteria:
- Non Asian-American men and women between the ages of 25-65 years
- Body Mass Index (BMI) ≥ 25 and ≤ 38 kg/m2
- Fasting LDL-cholesterol ≥ 130 mg/dL
- Willingness and ability to make scheduled appointments at clinical site as required
by study protocol
Exclusion Criteria:
- Major aversions to Korean foods
- Known food allergies that would interfere with study protocol
- Use of cholesterol-lowering medication or dietary supplements
- Use of blood pressure medications
- Use of prebiotics or probiotics in the last 3 months
- Received medication for bacterial infection (antibiotic) in the last 3 months
- Regular use of fiber supplements or laxatives
- Conditions requiring ongoing medical care and/or medication, including kidney, liver,
gastrointestinal or endocrine disorders.
- Regular tobacco use within 6 months prior to the start of the study
- History of eating disorders or other dietary patterns which are not consistent with
the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
- Voluntary or involuntary weight loss of 10% of body weight within the last 12 months
- Self-report of alcohol or substance abuse within the past 12 months
- Donated blood during the 8 week period prior to the study
- Other medical, psychiatric, or behavioral factors that in the judgment of the
Principal Investigator may interfere with study anticipation or the ability to follow
the intervention protocol
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