Analyses of Existing Framingham Data
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 30 - 100 |
| Updated: | 3/22/2019 |
| Start Date: | June 25, 2003 |
| End Date: | April 25, 2018 |
Continued Analyses of Epidemiologic Risk Factors Using Existing Framingham Eye and Heart Study Data
Since 1948, the Framingham Study has examined a group of men and women every two years for
the primary purpose of studying the incidence and prevalence of cardiovascular disease and
its risk factors. In 1971 the Framingham Study began a study of the offspring of the original
group, including data collection on blood pressure, cigarette smoking, weight, and other
factors that are of interest to studies of eye disease. Researchers gave eye exams to some of
the original group and to the offspring group. Data from these eye exams have been used to
examine risk factors for cataracts, diabetic retinopathy, myopia, and glaucoma.
The purpose of this study is to use the previously collected data for continued research on
eye-related disorders. No new eye examinations will be conducted.
the primary purpose of studying the incidence and prevalence of cardiovascular disease and
its risk factors. In 1971 the Framingham Study began a study of the offspring of the original
group, including data collection on blood pressure, cigarette smoking, weight, and other
factors that are of interest to studies of eye disease. Researchers gave eye exams to some of
the original group and to the offspring group. Data from these eye exams have been used to
examine risk factors for cataracts, diabetic retinopathy, myopia, and glaucoma.
The purpose of this study is to use the previously collected data for continued research on
eye-related disorders. No new eye examinations will be conducted.
We propose to continue to analyze existing Framingham Eye and Heart Study data to identify
possible risk factors for various eye diseases. Originally begun in 1948 by the National
Heart, Lung and Blood Institute (NHLBI), the Framingham Heart Study has been examining a
population-based cohort of men and women biennially since 1948 for the primary purpose of
studying the incidence and prevalence of cardiovascular disease and its risk factors. In 1971
the Heart Study began a prospective study of the offspring of the original cohort. The Heart
Study has collected data on blood pressure, cigarette smoking, weight and many other factors
of interest for epidemiologic studies of eye disease. Eye examinations were conducted on the
survivors of the original cohort in a collaborative effort between the NEI and the NHLBI
between 1973 and 1975 (Framingham Eye Study I; FES I) and then again between 1986 and 1989
(Framingham Eye Study II; FES II). Eye examinations were conducted on the Offspring Cohort
from 1989 to 1991 (Framingham Offspring Eye Study; FOES). The Framingham data are unique in
allowing epidemiologic studies with both cross sectional and longitudinal designs. Over the
years, data from the Heart Study and the various eye studies have been used to examine
demographic and risk factor characteristics for cataract, diabetic retinopathy, myopia, and
glaucoma. To date this collaborative effort has yielded 31 publications by the National Eye
Institute's Division of Epidemiology and Clinical Research; Rita Hiller is an author of 11.
This proposal is for the continued use of the previously collected Framingham data. All
studies will be done in collaboration with Heart Study investigators from Boston University
which manages the study and conducts annual IRB reviews. No new eye examinations will be
done.
possible risk factors for various eye diseases. Originally begun in 1948 by the National
Heart, Lung and Blood Institute (NHLBI), the Framingham Heart Study has been examining a
population-based cohort of men and women biennially since 1948 for the primary purpose of
studying the incidence and prevalence of cardiovascular disease and its risk factors. In 1971
the Heart Study began a prospective study of the offspring of the original cohort. The Heart
Study has collected data on blood pressure, cigarette smoking, weight and many other factors
of interest for epidemiologic studies of eye disease. Eye examinations were conducted on the
survivors of the original cohort in a collaborative effort between the NEI and the NHLBI
between 1973 and 1975 (Framingham Eye Study I; FES I) and then again between 1986 and 1989
(Framingham Eye Study II; FES II). Eye examinations were conducted on the Offspring Cohort
from 1989 to 1991 (Framingham Offspring Eye Study; FOES). The Framingham data are unique in
allowing epidemiologic studies with both cross sectional and longitudinal designs. Over the
years, data from the Heart Study and the various eye studies have been used to examine
demographic and risk factor characteristics for cataract, diabetic retinopathy, myopia, and
glaucoma. To date this collaborative effort has yielded 31 publications by the National Eye
Institute's Division of Epidemiology and Clinical Research; Rita Hiller is an author of 11.
This proposal is for the continued use of the previously collected Framingham data. All
studies will be done in collaboration with Heart Study investigators from Boston University
which manages the study and conducts annual IRB reviews. No new eye examinations will be
done.
- This study is of existing ocular data from the Framingham Eye Study. Since the
participants have already been recruited, there are no further exclusions from the
study.
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