Study to Evaluate the Efficacy of Etanercept Treatment in Adults Who Failed Therapy With Apremilast

This is a multicenter, open-label, single-arm, phase 4, estimation study in adults with
plaque psoriasis (PsO) who have failed apremilast. The study will consist of a screening
period of up to 45 days, a 24-week treatment period with study visits every 4 weeks, and a
30-day follow-up period for safety. Etanercept dosing will follow the recommended label
dosing for adults with plaque psoriasis.

Inclusion Criteria:

- Subject has provided informed consent prior to initiation of any study specific
activities/procedures

- Male or female subject is ≥ 18 years of age at time of screening

- Subject is a candidate for systemic therapy or phototherapy in the opinion of the
investigator

- Subject has moderate to severe plaque psoriasis (PsO) with involved body surface area
(BSA) ≥ 10%, psoriasis area and severity index (PASI) ≥ 10 and static physician's
global assessment (sPGA) ≥ 3 at screening and baseline

- Subject is currently receiving treatment with apremilast for moderate to severe plaque
PsO or subject has discontinued treatment with apremilast for PsO within the past 3
months prior to screening

- Subject has failed therapy with apremilast for moderate to severe plaque PsO defined
as either (1) failure to achieve adequate clinical response in the opinion of the
investigator, (2) loss of adequate clinical response in the opinion of the
investigator or (3) intolerability to apremilast in the opinion of the investigator

- Subject has received at least 4 weeks of apremilast treatment for moderate to severe
plaque PsO (this only applies for subjects who are qualifying by failure to achieve
adequate clinical response or loss of adequate clinical response, this does not apply
for subjects who are qualifying by intolerability to apremilast)

- Subject has not had significant known weight increase or decrease (≥ 10%) during
apremilast treatment

- Subject is < 264 lbs at screening and baseline -Subject has a negative test for
hepatitis B surface antigen, hepatitis B core antibody and hepatitis C antibody

- Subject has no known history of tuberculosis.

Exclusion Criteria:

Skin disease related

-Subject has active erythrodermic, pustular, guttate psoriasis, or medication induced
psoriasis, or other skin conditions at the time of the screening visit (for example,
eczema) that would interfere with evaluations of the effect of investigational product on
PsO.

Other Medical Conditions

- Subject has one or more significant concurrent medical conditions per investigator
judgment, including the following

- Poorly controlled diabetes

- Chronic kidney disease stage IIIb, IV, or V

- Symptomatic heart failure (New York Heart Association class II, III, or IV)

- Myocardial infarction or unstable angina pectoris within the past 12 months prior to
randomization

- Uncontrolled hypertension

- Severe chronic pulmonary disease (eg, requiring oxygen therapy)

- Multiple sclerosis or any other demyelinating disease

- Liver disease

- Anemia

- Major chronic inflammatory disease or connective tissue disease other than psoriasis
and/or psoriatic arthritis (for example, systemic lupus erythematosus with the
exception of secondary Sjogren's syndrome)

- Subject has active malignancy, including evidence of cutaneous basal or squamous cell
carcinoma or melanoma, Merkel cell carcinoma or history of cancer (other than fully
resected and surgically cured cutaneous basal cell and squamous cell carcinoma) within
5 years before the first dose of investigational product.