Annular Array Ultrasound in Ophthalmology
| Status: | Completed |
|---|---|
| Conditions: | Ocular, Diabetes |
| Therapuetic Areas: | Endocrinology, Ophthalmology |
| Healthy: | No |
| Age Range: | 60 - 90 |
| Updated: | 2/1/2019 |
| Start Date: | October 2011 |
| End Date: | December 2016 |
High-frequency-ultrasound Annular Arrays for Ophthalmic Imaging
The objective of this research is to improve the care of ocular disease and disorders, in
particular the changes in the eye associated with diabetes, by providing clinicians with
dramatically improved ultrasonic images of the entire eye. The research combines advanced
high-frequency, high-resolution ultrasonic annular arrays transducers with new processing
techniques designed to overcome several limits that have been reached with conventional high
frequency ultrasound systems. The investigators propose that diagnosis of eye diseases using
annular arrays can be more effective than the conventional ultrasound images by at least 50%;
i.e., that for every 2 posterior vitreous detachments detected conventionally, 3 will be
detected with the annular arrays.
particular the changes in the eye associated with diabetes, by providing clinicians with
dramatically improved ultrasonic images of the entire eye. The research combines advanced
high-frequency, high-resolution ultrasonic annular arrays transducers with new processing
techniques designed to overcome several limits that have been reached with conventional high
frequency ultrasound systems. The investigators propose that diagnosis of eye diseases using
annular arrays can be more effective than the conventional ultrasound images by at least 50%;
i.e., that for every 2 posterior vitreous detachments detected conventionally, 3 will be
detected with the annular arrays.
The goal of this study is to develop and evaluate advanced annular-array transducer
technology for rapid, high-definition imaging. The study will assess high frequency
ultrasound (HFU, 40 & 20 MegaHertz) annular arrays in imaging posterior vitreous detachments
(PVDs) associated with diabetic retinopathy, the leading cause of blindness in the US
working-age population according to Prevent Blindness America. Current HFU instruments do not
use linear arrays for such applications because of a variety of technical and cost reasons.
Instead, current HFU instruments use mechanically scanned, single-element transducers, which
provide fine-resolution images over a very limited depth of field (DOF). For ophthalmic
applications, a shallow DOF causes most ocular anatomy to be imaged with poor definition
compared to the in-focus region; therefore, because only a small portion of the eye is in
focus at a given time, detection and assessment of ocular conditions such as PVD are prone to
inaccuracies and false-negative determinations. Annular-array transducers offer a promising
approach to significantly extend DOF and to increase the depth range over which fine-lateral
resolution is provided. The investigators will validate system performance using animal
experiments and human-subject examinations. First, in vivo animal experiments will be
conducted to evaluate a 40-MegaHertz (MHz) annular array for anterior-segment imaging and a
20-MHz annular array for posterior segment and full-globe imaging. The investigators will
test the hypothesis that 20-MHz annular arrays improve detection of PVD. Validation of this
hypothesis will significantly improve our ability to assess disease status in diabetic
retinopathy.
technology for rapid, high-definition imaging. The study will assess high frequency
ultrasound (HFU, 40 & 20 MegaHertz) annular arrays in imaging posterior vitreous detachments
(PVDs) associated with diabetic retinopathy, the leading cause of blindness in the US
working-age population according to Prevent Blindness America. Current HFU instruments do not
use linear arrays for such applications because of a variety of technical and cost reasons.
Instead, current HFU instruments use mechanically scanned, single-element transducers, which
provide fine-resolution images over a very limited depth of field (DOF). For ophthalmic
applications, a shallow DOF causes most ocular anatomy to be imaged with poor definition
compared to the in-focus region; therefore, because only a small portion of the eye is in
focus at a given time, detection and assessment of ocular conditions such as PVD are prone to
inaccuracies and false-negative determinations. Annular-array transducers offer a promising
approach to significantly extend DOF and to increase the depth range over which fine-lateral
resolution is provided. The investigators will validate system performance using animal
experiments and human-subject examinations. First, in vivo animal experiments will be
conducted to evaluate a 40-MegaHertz (MHz) annular array for anterior-segment imaging and a
20-MHz annular array for posterior segment and full-globe imaging. The investigators will
test the hypothesis that 20-MHz annular arrays improve detection of PVD. Validation of this
hypothesis will significantly improve our ability to assess disease status in diabetic
retinopathy.
Inclusion Criteria:
- over age 60
- people with diabetic retinopathy or posterior vitreous detachments
Exclusion Criteria:
- under age 60
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Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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