Hereditary Risk Factors for Thyroid Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Endocrine, Thyroid Cancer |
| Therapuetic Areas: | Endocrinology, Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 8/18/2018 |
| Start Date: | March 1, 2016 |
| End Date: | March 1, 2021 |
| Contact: | Junne Kamihara, MD, PhD |
| Phone: | 617.632.3044 |
Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in
families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in
children and families, with a particular interest in understanding genes and other factors
that may put individuals at risk for developing thyroid cancer and thyroid nodules.
- In this study, family and medical history information is collected alongside a blood or
saliva sample for genetic studies.
- Individuals with a past or present childhood thyroid cancer/nodule or a thyroid cancer
suspected to be inherited in their family are invited to participate.
families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in
children and families, with a particular interest in understanding genes and other factors
that may put individuals at risk for developing thyroid cancer and thyroid nodules.
- In this study, family and medical history information is collected alongside a blood or
saliva sample for genetic studies.
- Individuals with a past or present childhood thyroid cancer/nodule or a thyroid cancer
suspected to be inherited in their family are invited to participate.
The purpose of this research study is to learn more about risk factors for inherited thyroid
cancer.
The investigators would like to use the participant DNA to look for alterations in genes. The
investigator will perform DNA sequencing and other genetic studies to identify errors in the
genes that may contribute to the formation of thyroid nodules and cancer.
cancer.
The investigators would like to use the participant DNA to look for alterations in genes. The
investigator will perform DNA sequencing and other genetic studies to identify errors in the
genes that may contribute to the formation of thyroid nodules and cancer.
Inclusion Criteria:
- Individual pediatric patient with current or previous known or suspected thyroid
cancer or nodule(s).
- Individual adult patient with current or previous known or suspected thyroid cancer or
nodule(s) if they come from a family with a high suspicion of hereditary cancer (as
below).
- Individuals from families with a high suspicion of hereditary thyroid cancer:
- Families with a current or previous diagnosis of a thyroid cancer/nodule
occurring in childhood (<18 years old).
- Families with a high suspicion of hereditary thyroid cancer/nodules other than
above to include:
- Families with thyroid cancer in multiple individuals
- Families with thyroid cancer and a known genetic syndrome
- Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple
childhood cancers in the family, multiple primary cancers, multiple
endocrinopathies, etc.)
Exclusion Criteria:
- Individuals who are unable to give informed consent.
- Individuals who are unable to complete study materials.
We found this trial at
1
site
450 Brookline Ave
Boston, Massachusetts 2215
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Junne Kamihara, MD, PhD
Phone: 617-632-3044
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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