Lung Microbiome and Inflammation in Early COPD
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 6/8/2018 |
| Start Date: | May 2014 |
| End Date: | August 2020 |
| Contact: | Kathryn Norris |
| Email: | Kathryn.Norris@nyumc.org |
Lung Microbiome and Inflammation in Early Chronic Obstructive Pulmonary Disease (COPD)
This is a cross sectional case controlled study to assess lung microbiome and inflammation in
smokers with and without Chronic Obstructive Pulmonary Disease (COPD). Investigators will
look at active bacterial metabolic pathways in the lower airways using metagenomic and
metabolomic approaches an assess relationships among microbiome, metagenome, metabolome and
host immune responses in COPD and controls. Investigators believe COPD cases will have higher
prevalence of pneumotype supraglottic predominant taxa (SPT) than matched controls.
smokers with and without Chronic Obstructive Pulmonary Disease (COPD). Investigators will
look at active bacterial metabolic pathways in the lower airways using metagenomic and
metabolomic approaches an assess relationships among microbiome, metagenome, metabolome and
host immune responses in COPD and controls. Investigators believe COPD cases will have higher
prevalence of pneumotype supraglottic predominant taxa (SPT) than matched controls.
Inclusion Criteria:
- Case definition: Smokers (>20 pack-year) with airflow obstruction (FEV1/FVC<70) and
FEV1>50% predicted (early COPD GOLD 1 or 2)
- Control definition: Smokers with normal spirometry will serve as controls.
Exclusion Criteria:
- FEV1 < 50% NOT 70
- Significant cardiovascular disease defined as abnormal EKG, known or suspected
coronary artery disease or congestive heart failure.
- Diabetes mellitus
- Significant liver or renal disease
- Severe coagulopathy (INR > 1.4, PTT > 40 seconds and platelet count < 150x103 cells).
- Pregnancy
- ETOH use of more than >6 beers or >4 mixed drinks daily
- Lack of capacity to provide informed consent.
- Antibiotic use within the prior 2months
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