Oklahoma Native American Women's Osteoporosis Screening Study
| Status: | Completed |
|---|---|
| Conditions: | Osteoporosis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 3/10/2019 |
| Start Date: | October 2007 |
| End Date: | March 2011 |
Native American women may be considered high risk for osteoporosis due to lifestyle factors
and incidence of type 2 diabetes. The objectives of this study are to: 1) determine the
prevalence of osteopenia/osteoporosis in Native American female volunteers; 2) to evaluate
their rate of bone loss; 3) to assess the relationship between lifestyle factors,
inflammatory mediators, and select endocrine parameters on osteoporosis risk; and 4)
determine the barriers to treatment. Participants will undergo a baseline, Year 1 and Year 2
follow-up osteoporosis risk assessment. Data will be analyzed using repeated measures ANOVA
and logistical regression.
and incidence of type 2 diabetes. The objectives of this study are to: 1) determine the
prevalence of osteopenia/osteoporosis in Native American female volunteers; 2) to evaluate
their rate of bone loss; 3) to assess the relationship between lifestyle factors,
inflammatory mediators, and select endocrine parameters on osteoporosis risk; and 4)
determine the barriers to treatment. Participants will undergo a baseline, Year 1 and Year 2
follow-up osteoporosis risk assessment. Data will be analyzed using repeated measures ANOVA
and logistical regression.
Osteoporosis, characterized by decreased bone density and deterioration in bone
microarchitecture, is estimated to afflict 1 out of 2 women over the age of 50 years. These
estimates are based primarily on Caucasian populations with limited information in Native
Americans. Native American women may be considered high risk for osteoporosis due to
lifestyle factors in conjunction with the incidence of diabetes. The objectives of this study
are to: 1) determine the prevalence of osteopenia/osteoporosis in Native American female
volunteers, aged 50+ years, who are eligible for health care through Indian Health Services;
2) to evaluate their rate of bone loss, 3) to assess the relationship between lifestyle
factors, inflammatory mediators, and select endocrine parameters on osteoporosis risk; and 4)
determine the barriers to treatment. Native American women aged, 50+ years, who are eligible
for services through Indian Health Services in the Oklahoma City (OKC) Area will be
recruited. Participants will undergo a baseline osteoporosis risk assessment, i.e. medical
history, dual-energy x-ray absorptiometry (DXA) scans, dietary and physical activity
assessment, and optional blood draw, and then encouraged to return to their primary care
physician for counsel and/or treatment. Serum markers of bone metabolism, endocrine
parameters (e.g. vitamin D metabolites) and inflammatory molecules will be assessed for
participants that consent to the blood draw. All participants will receive educational
information related to osteoporosis risk and prevention, and follow-up visits scheduled at
the end of Year 1 and Year 2. Data will be analyzed using repeated measures ANOVA and
logistical regression with the α set at 0.05 for statistical significance.
microarchitecture, is estimated to afflict 1 out of 2 women over the age of 50 years. These
estimates are based primarily on Caucasian populations with limited information in Native
Americans. Native American women may be considered high risk for osteoporosis due to
lifestyle factors in conjunction with the incidence of diabetes. The objectives of this study
are to: 1) determine the prevalence of osteopenia/osteoporosis in Native American female
volunteers, aged 50+ years, who are eligible for health care through Indian Health Services;
2) to evaluate their rate of bone loss, 3) to assess the relationship between lifestyle
factors, inflammatory mediators, and select endocrine parameters on osteoporosis risk; and 4)
determine the barriers to treatment. Native American women aged, 50+ years, who are eligible
for services through Indian Health Services in the Oklahoma City (OKC) Area will be
recruited. Participants will undergo a baseline osteoporosis risk assessment, i.e. medical
history, dual-energy x-ray absorptiometry (DXA) scans, dietary and physical activity
assessment, and optional blood draw, and then encouraged to return to their primary care
physician for counsel and/or treatment. Serum markers of bone metabolism, endocrine
parameters (e.g. vitamin D metabolites) and inflammatory molecules will be assessed for
participants that consent to the blood draw. All participants will receive educational
information related to osteoporosis risk and prevention, and follow-up visits scheduled at
the end of Year 1 and Year 2. Data will be analyzed using repeated measures ANOVA and
logistical regression with the α set at 0.05 for statistical significance.
Inclusion Criteria:
- Native American women who are eligible fore services at Indian Health Clinics in OKC
- 50 years of age or older
Exclusion Criteria:
- Women who weigh more than 300 lbs or who are pregnant or cognitively impaired
We found this trial at
1
site
940 NE 13th St
Oklahoma City, Oklahoma 73190
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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