Quantifying Quadriceps Atrophy Following Tibial Plateau Fracture
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 12/27/2018 |
| Start Date: | October 2015 |
| End Date: | October 2019 |
This study will quantify and examine the extent to which the quadriceps femoris muscle group
atrophies following tibial plateau fractures and the length of time that atrophy affects
function. The study will also look at the effects of tibial plateau fractures on the
quadriceps muscle and the effect this atrophy has on functional outcome. Quadriceps atrophy
will be measured both clinically and by using MRI scans taken pre-operatively, 3 months post
operatively, and 1 year post-operatively. The injured leg and the non-injured leg will be
scanned in order for the non-injured leg to serve as the control. In this way muscle volume
can be estimated from the muscle thickness at specific locations in the thigh. The muscle
strength of the quadriceps will also be assessed at the 3 month and 1 year visit by measuring
isokinetic knee-extension torque, and functional assessment questionnaires will be completed
at each study visit.
atrophies following tibial plateau fractures and the length of time that atrophy affects
function. The study will also look at the effects of tibial plateau fractures on the
quadriceps muscle and the effect this atrophy has on functional outcome. Quadriceps atrophy
will be measured both clinically and by using MRI scans taken pre-operatively, 3 months post
operatively, and 1 year post-operatively. The injured leg and the non-injured leg will be
scanned in order for the non-injured leg to serve as the control. In this way muscle volume
can be estimated from the muscle thickness at specific locations in the thigh. The muscle
strength of the quadriceps will also be assessed at the 3 month and 1 year visit by measuring
isokinetic knee-extension torque, and functional assessment questionnaires will be completed
at each study visit.
Inclusion Criteria:
- All racial and ethnic groups
- Diagnosis of tibial plateau fracture
- Patients who opt for surgical treatment or non-operative treatment of their fracture
- Patients who consent to undergoing 3 MRI scans
- Patients who are willing to follow-up for a minimum of 52 weeks
Exclusion Criteria:
- Patients younger than 18 years old or older than 65
- Patients who may be pregnant or may become pregnant in the 52 weeks following injury
- Patients who have electric, magnetic, or mechanical devices currently implanted
- Patients who have abnormal ECG results
- Diagnosis of any additional lower extremity fractures other than tibial plateau
- Patients who fit the definition of a vulnerable population
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