Establishing a Repository of Blood and DNA Samples From People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Genotype-Phenotype Database and Sample Repository)



Status:Terminated
Conditions:Anemia
Therapuetic Areas:Hematology
Healthy:No
Age Range:Any
Updated:7/13/2016
Start Date:August 2007
End Date:September 2008

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Comprehensive Sickle Cell Centers (CSCC) Collaborative Genotype-Phenotype Database and Sample Repository

Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease
that can cause intense pain episodes. The purpose of this study is to collect, test, and
archive blood and DNA samples from children and adults with SCD to study the role that genes
play in SCD. Blood and DNA samples will be stored for use in future SCD studies.

SCD is an inherited blood disorder that is caused by an abnormal type of hemoglobin.
Symptoms include anemia, infections, organ damage, and intense episodes of pain, which are
called "sickle cell crises." The Comprehensive Sickle Cell Centers (CSCC) is a network of 10
centers that conduct research to improve health care and treatment options for people with
SCD. The Collaborative Data Project (C-Data) is a CSCC study that is establishing a
comprehensive database of children and adults with SCD who are receiving medical care at
participating CSCC research centers. This study will initiate the development of a
centralized laboratory that will collect, test, and archive blood and DNA samples from
participants in the C-Data project for use in future SCD studies. The collection of blood
and DNA samples will provide researchers with an important resource to better define the
genetic diversity of SCD. In the future, genotype-phenotype correlation studies, population
studies, and various other genetic studies may be conducted.

This study will enroll participants taking part in the C-Data project. For this study,
participants will undergo a blood collection. The blood sample will then be sent to a lab to
characterize the red blood cells and hemoglobin. DNA will be analyzed to identify genes that
influence the severity of SCD. Blood and DNA will be stored for future genetic research in
SCD and closely related disorders.

Inclusion Criteria:

- Participating in the C-Data project

Exclusion Criteria:

- Unable to undergo blood collection
We found this trial at
13
sites
7777 Forest Lane
Dallas, Texas 75235
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Bronx, NY
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Chapel Hill, North Carolina 27599
(919) 962-2211
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
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Philadelphia, Pennsylvania 19134
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Philadelphia, PA
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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Boston, Massachusetts 02115
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Boston, MA
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Boston, Massachusetts 02118
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Cincinnati, Ohio 45229
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Cincinnati, OH
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Dallas, TX
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Galveston, Texas 77555
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Oakland, California 94609
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San Francisco, California 94143
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San Francisco, CA
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