Study of Accuracy of New Diagnostic Technology to Guide Rapid Antibiotic Treatment for Serious Infections
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, Infectious Disease, Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/3/2017 |
| Start Date: | July 2015 |
| End Date: | December 2016 |
Rapid Microbiological Diagnostics for MDRO Quantitative Identification and Resistance Phenotyping to Guide Antibiotic Selection in Wounded Warriors and Veterans - Task 3
This research will test a new ultra-rapid technology (called ID/AST Accelerate system) that
uses a digital microscope to identify bacteria based on their growth patterns. This method
does not have to wait for bacteria to grow in a lab. The new method can identify the type of
bacteria within 2 hours of receiving a specimen. The new method also shows the effect of
selected antibiotics on the bacteria including multidrug resistant bacteria so that doctors
know within 6 hours from specimen collection which antibiotic kills the bacteria.
To check the accuracy, speed and impact of the new method on antibiotic prescribing,
investigators are proposing a study with two parts; The first part will test the accuracy
and speed of the results obtained by the new method. The second part will test if having the
results from the new method early would change the antibiotics prescribed to a patient in a
simulation experiment. An independent infectious disease physician will be shown the results
from the new method and asked if the results were accurate, would it change the antibiotic
treatment for the patient.
uses a digital microscope to identify bacteria based on their growth patterns. This method
does not have to wait for bacteria to grow in a lab. The new method can identify the type of
bacteria within 2 hours of receiving a specimen. The new method also shows the effect of
selected antibiotics on the bacteria including multidrug resistant bacteria so that doctors
know within 6 hours from specimen collection which antibiotic kills the bacteria.
To check the accuracy, speed and impact of the new method on antibiotic prescribing,
investigators are proposing a study with two parts; The first part will test the accuracy
and speed of the results obtained by the new method. The second part will test if having the
results from the new method early would change the antibiotics prescribed to a patient in a
simulation experiment. An independent infectious disease physician will be shown the results
from the new method and asked if the results were accurate, would it change the antibiotic
treatment for the patient.
Inclusion Criteria:
- Age ≥ 18 years old
- Remnant sample from available from microbiology culture (respiratory, blood or
tissue/skin) ordered as part of usual clinical care.
Exclusion Criteria:
- Insufficient sample volume available after sufficient aliquot removed for usual care.
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