Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator

This is a prospective, single-arm, multicenter, open-label clinical trial in which
participants will use the OIN once following study enrollment.

Inclusion Criteria:

- Subjects with dry eye disease

- Literate, able to speak English or Spanish, and able to complete questionnaires
independently

- Willing to sign the informed consent and deemed capable of complying with the
requirements of the study protocol

Exclusion Criteria:

- Chronic or recurrent epistaxis, coagulation disorders or other conditions that, in the
opinion of the investigator, may lead to clinically significant increased bleeding

- Nasal or sinus surgery (including history of application of nasal cautery) or
significant trauma

- Cardiac demand pacemaker, implanted defibrillator or other implanted electronic device

- Corneal transplant in either or both eyes

- Participation in any clinical trial with a new active substance or a new device within
30 days of the Screening Visit

- Women who are pregnant, planning a pregnancy, or nursing at the Screening Visit