A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia



Status:Terminated
Conditions:Alzheimer Disease, Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:55 - 85
Updated:8/25/2018
Start Date:June 16, 2016
End Date:July 2, 2018

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Effect of LY3202626 on Alzheimer's Disease Progression as Measured by Cerebral ¹⁸F-AV-1451 Tau-PET in Mild Alzheimer's Disease Dementia

The main purpose of this study is to evaluate the safety and the effect on brain tau of the
study drug LY3202626 in participants with mild Alzheimer's disease (AD) dementia.


Inclusion Criteria:

- Present with mild AD dementia based on the National Institute on Aging (NIA) and the
Alzheimer's Association (AA) disease diagnostic criteria as determined by a qualified
clinician approved by the Sponsor or designee.

- Mini-Mental State Examination score of 20 to 26 inclusive at screening visit.

- Has a florbetapir PET scan consistent with the presence of amyloid pathology at
screening.

Exclusion Criteria:

- Significant neurological disease affecting the central nervous system (CNS), other
than AD, that may affect cognition or ability to complete the study, including but not
limited to, other dementias, serious infection of the brain, Parkinson's disease,
multiple concussions, or epilepsy or recurrent seizures (except febrile childhood
seizures).

- Ocular pathology that significantly limits ability to reliably evaluate vision or the
retina.

- Use of strong inducers of cytochrome P450 3A (CYP3A).

- Sensitivity to florbetapir or ¹⁸F-AV-1451.

- Contraindication to MRI or PET or poor venous access for blood draws.
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Sacramento, California 95816
Principal Investigator: Shawn Kile
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1709 S Rock Rd
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47 New Scotland Ave
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Amherst, New York 14226
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733 North Broadway
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Charleston, South Carolina 29406
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Chesterfield, Missouri 63141
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340 W 10th St #6200
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