A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia



Status:Terminated
Conditions:Alzheimer Disease, Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:55 - 85
Updated:8/25/2018
Start Date:June 16, 2016
End Date:July 2, 2018

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Effect of LY3202626 on Alzheimer's Disease Progression as Measured by Cerebral ¹⁸F-AV-1451 Tau-PET in Mild Alzheimer's Disease Dementia

The main purpose of this study is to evaluate the safety and the effect on brain tau of the
study drug LY3202626 in participants with mild Alzheimer's disease (AD) dementia.


Inclusion Criteria:

- Present with mild AD dementia based on the National Institute on Aging (NIA) and the
Alzheimer's Association (AA) disease diagnostic criteria as determined by a qualified
clinician approved by the Sponsor or designee.

- Mini-Mental State Examination score of 20 to 26 inclusive at screening visit.

- Has a florbetapir PET scan consistent with the presence of amyloid pathology at
screening.

Exclusion Criteria:

- Significant neurological disease affecting the central nervous system (CNS), other
than AD, that may affect cognition or ability to complete the study, including but not
limited to, other dementias, serious infection of the brain, Parkinson's disease,
multiple concussions, or epilepsy or recurrent seizures (except febrile childhood
seizures).

- Ocular pathology that significantly limits ability to reliably evaluate vision or the
retina.

- Use of strong inducers of cytochrome P450 3A (CYP3A).

- Sensitivity to florbetapir or ¹⁸F-AV-1451.

- Contraindication to MRI or PET or poor venous access for blood draws.
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Monroe, New Jersey 08831
Principal Investigator: Jeffrey Greenberg
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104 SE 1st Avenue
Ocala, Florida 34471
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1709 S Rock Rd
Wichita, Kansas 67207
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Abington, Pennsylvania 19001
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47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
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Allentown, Pennsylvania 18104
Principal Investigator: Paul Gross
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Amherst, New York 14226
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733 North Broadway
Baltimore, Maryland 21205
(410) 955-3182
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Centerville, Ohio
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Charleston, South Carolina 29406
Principal Investigator: David Stickler
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Chesterfield, Missouri 63141
Principal Investigator: Siddharth Kaul
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Creve Coeur, Missouri 63141
Principal Investigator: Franco Sicuro
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Dallas, Texas 75219
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Dayton, Ohio 45414
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3230 Eden Avenue
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Eatontown, New Jersey 07724
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Fort Wayne, Indiana 46805
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Houston, Texas 77030
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Houston, Texas 77054
Principal Investigator: Paul Schulz
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340 W 10th St #6200
Indianapolis, Indiana 46202
(317) 274-3772
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Melbourne, Florida 32940
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Miami, Florida 33175
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Miami, Florida 33166
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Miami, Florida 33176
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New Port Richey, Florida 34652
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Newton, Massachusetts 02459
Principal Investigator: Paul Solomon
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Ocoee, Florida 34761
Principal Investigator: Kelly Taylor
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Sacramento, California 95816
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660 S Euclid Ave
Saint Louis, Missouri 63110
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San Diego, California 92123
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Shaker Heights, Ohio 44122
Principal Investigator: Deborah Gould
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120 Medical Boulevard
Spring Hill, Florida 34609
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Tampa, Florida 33609
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Toms River, New Jersey 08755
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Toms River, New Jersey 08755
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Topeka, Kansas 66606
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Wilmington, Delaware 19801
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