A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years of Age With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting.

This is a randomized, double-blind, placebo-controlled, parallel-group, efficacy and safety
study in children with ADHD in a laboratory classroom setting. The study will be comprised of
3 periods: Screening (up to 35 days) including a 3 - 5 day ADHD medication washout prior to
Day -1; Double-blind randomized treatment with either dasotraline (4 mg/day) or placebo for14
days; and End of Study (EOS) Visit (7 days after last dose). Prior to the start of treatment
(Day 1) and following the conclusion of the double-blind period (Day 15), subjects will
undergo a full-day laboratory classroom evaluation during which approximately 12 to 18
subjects will be assessed. Each laboratory classroom day will include seven 30-minute
simulated classroom sessions where trained observers will assess subjects using the Swanson,
Kotkin, Agler, M-Flynn, and Pelham (SKAMP) Scale. In addition during each classroom session,
a 10-minute math test (Permanent Product Measure of Performance [PERMP]) will be administered
to evaluate sustained attention and effort. Seven (± 2) days after the last dose of study
drug, subjects will return to the clinic and complete safety assessments.

Inclusion Criteria:

- 1. Subject is 6 - 12 years old, inclusive at screening and randomization. 2. At least
one of the subject's parents/legal guardians must give written informed consent,
including privacy authorization, prior to study participation. The subject will
provide informed assent prior to study participation.

3. Subject meets Diagnostic and Statistical Manual of Mental Disorders Fifth Edition
(DSM-5) criteria for a primary diagnosis of ADHD (inattentive, hyperactive, or
combined presentation) at screening established by a comprehensive psychiatric
evaluation that reviews DSM-5 criteria and confirmed using the Schedule for Affective
Disorders and Schizophrenia for School-Age Children-Present and Lifetime version
(K-SADS-PL) at screening.

4. Subject is currently on a treatment regimen of a methylphenidate formulation within
the approved labeled dose range for ADHD for at least 6 weeks prior to Day -7 with the
same dose level for at least 1 week immediately prior to Day -7. Note: if any doses of
methylphenidate were missed during the week prior to Day-7, the subject's eligibility
will be discussed with the Medical Monitor.

5. In the opinion of the investigator, methylphenidate well tolerated and clinically
effective based on clinical assessment and informant interview, as well as, review of
available medical records. Note: The ADHD Rating Scale Version IV - Home Version
(modified for investigator administration) (ADHD-RS-IV HV) will be administered at
Screening by the investigator to inform clinical evaluation.

6. Subject is male or a non-pregnant, non-lactating female. 7. Subject, if female,
must not be pregnant or breastfeeding, and if ≥ 8 years of age must have a negative
serum pregnancy test at screening.

8. Female subjects of childbearing potential and male subjects with female partners of
childbearing potential must practice true abstinence (consistent with lifestyle) and
must agree to remain abstinent or agree to use an effective and medically acceptable
form of birth control, from the time of informed consent/assent to at least 14 days
after the last dose of the study drug has been taken.

9. Subject must be in general good health (defined as the absence of any clinically
relevant abnormalities as determined by the investigator) based on screening physical
and neurological examinations, medical history, and clinical laboratory values
(hematology, chemistry, and urinalysis). Note: If any of the hematology, chemistry, or
urinalysis results are not within the laboratory's reference range, then the subject
can be included only if the investigator determines the deviations to be not
clinically relevant.

10. Subject is within the 3rd to 97th percentile for gender specific body mass index
(BMI)-for-age from the World Health Organization (WHO) growth charts and weighs at
least 21 kg.

11. Subject must report a history of being able to swallow capsules. 12. Subject and
subject's parent/legal guardian must be able to fully comprehend the informed
consent/assent forms, understand and be willing and able to comply with all study
procedures and visit schedule, and be able to communicate satisfactorily with the
investigator and study coordinator.

Exclusion Criteria:

- 1. Subject or parent/legal guardian has commitments during the study that would
interfere with attending study visits.

2. Subject, on Day 1, has not demonstrated evidence of worsening of ADHD symptoms as
measured by ADHD-RS-IV HV total score ≥ 26 and at least a 30% worsening in ADHD-RS-IV
HV total score since the last assessment and following a minimum 72-hour washout from
prior methylphenidate treatment.

3. Subject is currently being treated for ADHD with an amphetamine-based product, or
has been treated with an amphetamine-based product in the 6 weeks prior to the start
of screening.

4. Subject is currently being treated for ADHD with a non-methylphenidate product, or
has been treated with a non-methylphenidate product in the 6 weeks prior to the start
of screening.

5. Subject has failed 2 adequate courses (dose and duration) of stimulant or
non-stimulant treatment for ADHD, as judged by the investigator.

6. Subject currently has a diagnosis of asthma that has required daily treatment with
bronchodilators or nebulizer treatments in the 30 days prior to screening and/or who
may require daily treatments with these agents over the course of the trial.
Intermittent use of bronchodilators is not exclusionary. Subjects who have a history
of requiring persistent asthma treatment should be discussed with the medical monitor
prior to randomization.

7. Subject has any clinically significant unstable medical abnormality, chronic
disease, or a history of a clinically significant abnormality of the cardiovascular,
gastrointestinal, respiratory, hepatic, or renal systems, or a disorder or history of
a condition (eg, malabsorption, gastrointestinal surgery) that may interfere with drug
absorption, distribution, metabolism, or excretion. Note: Active medical conditions
that are minor or well-controlled are not exclusionary if they do not affect risk to
the subject or the study results. In cases in which the impact of the condition upon
risk to the subject or study results is unclear, the medical monitor should be
consulted. Any subject with a known cardiovascular disease or condition (even if
controlled) must be discussed with the medical monitor during screening.

8. Subject has a history or presence of abnormal ECGs, which in the investigator's
opinion is clinically significant. Screening site ECGs will be centrally over-read,
and eligibility will be determined by the investigator based on the results of the
over-read report.

9. Subject has any diagnosis of bipolar I or II disorder, major depressive disorder,
conduct disorder, obsessive-compulsive disorder, any history of psychosis, autism
spectrum disorder, disruptive mood dysregulation disorder (DMDD), intellectual
disability, Tourette's Syndrome, confirmed genetic disorder with cognitive and/or
behavioral disturbances. Note: Subjects with oppositional defiant disorder (ODD) are
permitted to enroll in the study as long as ODD is not the primary focus of treatment.

10. Subject has generalized anxiety disorder or panic disorder that has been the
primary focus of treatment at any time during the 12 months prior to screening or that
has required pharmacotherapy any time during the 6 months prior to screening.

11. Subject has evidence of any chronic disease of the central nervous system (CNS)
such as tumors, inflammation, seizure disorder, vascular disorder, potential CNS
related disorders that might occur in childhood (eg, Duchenne Muscular dystrophy,
myasthenia gravis, or other neurologic or serious neuromuscular disorders), or history
of persistent neurological symptoms attributable to serious head injury. Past history
of febrile seizure, drug-induced seizure, or alcohol withdrawal seizure is
exclusionary. Subject taking anticonvulsants for seizure control currently or within
the past 2 years is not eligible for study participation.

12. Subject has uncontrolled thyroid disorder as evidenced by thyroid stimulating
hormone (TSH) ≤ 0.8 x the lower limit of normal (LLN) or ≥ 1.25 x the upper limit of
normal (ULN) for the reference laboratory.

13. Subject answers "yes" to "Suicidal Ideation" item 4 (active suicidal ideation with
some intent to act, without specific plan) or item 5 (active suicidal ideation with
specific plan and intent) for any lifetime history on the C-SSRS Children's
Lifetime/Recent assessment at screening.

14. Subject has any history of attempted suicide or clinically significant suicidal
ideation, in the opinion of the investigator.

15. Subject has a history of severe allergies to more than 1 class of medication or
multiple adverse drug reactions or has a history of allergic reaction or has a known
or suspected sensitivity to any substance that is contained in the study drug
formulations.

16. Subject has history of intolerance (safety) or lack of efficacy to stimulants.

17. Subject has taken any antipsychotic medication within 6 months prior to screening.

18. Subject has taken any herbal and/or complementary treatments, eg, St. John's Wort,
within 7 days prior to Day 1.

19. Subject has taken any antidepressant medication (eg, bupropion, selective
serotonin reuptake inhibitor [SSRI]/ serotonin norepinephrine reuptake inhibitor
[SNRI], tricyclic, etc) within 7 days prior to Day 1.

20. Subject has taken any monoamine oxidase [MAO] inhibitor within 21 days prior to
Day 1.

21. Subject is currently undergoing Cognitive Behavioral Therapy (CBT) for the
treatment of ADHD, has initiated behavioral therapy (including school based
interventions) less than 1 month prior to screening, or is receiving behavioral
therapy and in the opinion of the investigator will not be able to follow a stable
routine for the duration of the study. Note: Unavoidable changes in school-based
interventions that occur during study participation will not be exclusionary, but
should be documented by the investigator, to the extent possible.

22. Subject or subject's family anticipates a move outside the geographic range of
investigative site during the study period, or plans extended travel inconsistent with
the recommended visit interval during study duration.

23. Subject has history of, or current malignancy except for non-melanomatous skin
cancer.

24. Subject has history of positive test for Hepatitis B surface antigen or Hepatitis
C antibody.

25. Subject is known to have tested positive for human immunodeficiency virus (HIV).

26. Subject has participated in a classroom study within 6 months prior to the start
of screening or has participated in any other clinical study with an investigational
drug/product within 90 days prior to the start of screening or is currently
participating in another clinical trial.

27. Subject shows evidence of substance or alcohol use or is currently using tobacco
or other nicotine-containing products, or has a positive urine drug screen (UDS) at
screening. Note: Subjects with a positive UDS may be allowed to continue in the study,
provided that the investigator determines that the positive test is as a result of
taking medications as prescribed after consultation with the medical monitor.

28. Subject is taking any disallowed medications for chronic treatment. 29. Subject
has previously been enrolled in a clinical trial of dasotraline (SEP-225289).

30. Subject's parent/legal guardian is an investigational site staff member or the
relative of an investigational site staff member.

31. Subject is, in the opinion of the investigator, unsuitable in any other way to
participate in this study.

32. Subject's sibling or family member living in the same household is participating
in the same laboratory classroom cohort for this study.

33. Subject is unable to perform at the basic level of the standardized math test as
defined in the laboratory classroom manual.