Phase Ib Study of Anetumab Ravtansine in Combination With Pegylated Liposomal Doxorubicin in Patients With Recurrent Mesothelin-expressing Platinum-resistant Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Ovarian Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/8/2019 |
| Start Date: | June 8, 2016 |
| End Date: | February 28, 2021 |
| Contact: | Bayer Clinical Trials Contact |
| Email: | clinical-trials-contact@bayer.com |
| Phone: | (+) 1-888-8422937 |
An Open-label Phase Ib Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Maximum Tolerated Dose of Anetumab Ravtansine in Combination With Pegylated Liposomal Doxorubicin 30 mg/m2 Given Every 3 Weeks in Subjects With Mesothelin-expressing Platinum-resistant Recurrent Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Anetumab ravtansine is developed for the treatment of patients with recurrent
platinum-resistant ovarian cancer. The purpose of the proposed trial is to identify the
maximum tolerated dose of anetumab ravtansine that could be safely combined with pegylated
liposomal doxorubicin in this indication.
platinum-resistant ovarian cancer. The purpose of the proposed trial is to identify the
maximum tolerated dose of anetumab ravtansine that could be safely combined with pegylated
liposomal doxorubicin in this indication.
Inclusion Criteria:
- Subjects with locally invasive or metastatic, epithelial ovarian, fallopian tube, or
primary peritoneal cancer
- Subjects must provide samples of tumor tissue
- Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0 or 1
Exclusion Criteria:
- Subjects with low-grade ovarian, fallopian tube, or Primary peritoneal cancer
- Women who are pregnant or breast feeding
- Subjects who have an active hepatitis B virus or hepatitis C virus infection requiring
treatment as defined in the protocol
We found this trial at
7
sites
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
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University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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