Detection of Pathological Lymphocytes in Patients With Autoimmune Disease
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Arthritis, Rheumatoid Arthritis, Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases, Rheumatology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 3/27/2019 |
| Start Date: | August 2011 |
| End Date: | September 2020 |
This study will help the investigators design a method to detect the disease-causing immune
cells in patients with rheumatoid arthritis (RA). Such methods are not currently available,
but if successful, would help scientists to better understand the causes of RA.
cells in patients with rheumatoid arthritis (RA). Such methods are not currently available,
but if successful, would help scientists to better understand the causes of RA.
The investigators are interested in learning about the immune cells in the blood that
contribute to disease in patients with rheumatoid arthritis (RA). They have developed a
method for identifying a specific type of immune cells that can react against normal tissues
in the body.
In this study, the investigators will enroll RA patients from the University of Minnesota
clinics, collect blood samples from enrolled patients, and process the blood samples to
isolate DNA, RNA, serum, and blood cells. They will use the serum to detect whether specific
autoantibodies (Anti-cyclic Citrullinated Peptide, or anti-CCP) are present. In cases where
anti-CCP antibodies are detected, the investigators may quantify the numbers of immune cells
present that contain receptors with the same anti-CCP specificity. They may also test whether
the numbers of immune cells with these receptors correlate with measures of disease activity
in RA patients.
contribute to disease in patients with rheumatoid arthritis (RA). They have developed a
method for identifying a specific type of immune cells that can react against normal tissues
in the body.
In this study, the investigators will enroll RA patients from the University of Minnesota
clinics, collect blood samples from enrolled patients, and process the blood samples to
isolate DNA, RNA, serum, and blood cells. They will use the serum to detect whether specific
autoantibodies (Anti-cyclic Citrullinated Peptide, or anti-CCP) are present. In cases where
anti-CCP antibodies are detected, the investigators may quantify the numbers of immune cells
present that contain receptors with the same anti-CCP specificity. They may also test whether
the numbers of immune cells with these receptors correlate with measures of disease activity
in RA patients.
Inclusion Criteria:
- Diagnosis of rheumatoid arthritis
Exclusion Criteria:
- Use of rituximab immediately prior to visit
- Pregnancy
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