Fish Oil T Cell Function
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cognitive Studies, Cognitive Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 55 - Any |
| Updated: | 9/9/2017 |
| Start Date: | January 2016 |
| End Date: | June 2018 |
Nutritional Intervention to Test Effect on Healthy Human T Cell Function
The purpose of the study is to examine the effect of dietary n-3 polyunsaturated fatty acid
supplementation on subjects' pan CD4+ T cell function, cognition, and muscle function. Half
of the participants will receive fish oil, while the other half will receive a placebo (olive
oil).
supplementation on subjects' pan CD4+ T cell function, cognition, and muscle function. Half
of the participants will receive fish oil, while the other half will receive a placebo (olive
oil).
Generalized inflammation has been consistently associated with aging and metabolic diseases,
often characterized by reduced muscle and cognitive function. Although much of the
aging-associated inflammation has been attributed to chronic activation of the innate host
defense system, activated CD4+ T cells have been shown to contribute directly to the
pathogenesis of several other inflammatory diseases. In humans, dietary n-3 polyunsaturated
fatty acids (PUFA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA),
have anti-inflammatory properties and reduce disease symptoms, in part, through suppression
of CD4+ T cell activation. Therefore, the Researchers' overall hypothesis is that dietary
supplementation with DHA and EPA in humans will ameliorate inflammatory symptoms, in part, by
suppressing CD4+ T cell activation, positively affecting muscle and cognitive function.
often characterized by reduced muscle and cognitive function. Although much of the
aging-associated inflammation has been attributed to chronic activation of the innate host
defense system, activated CD4+ T cells have been shown to contribute directly to the
pathogenesis of several other inflammatory diseases. In humans, dietary n-3 polyunsaturated
fatty acids (PUFA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA),
have anti-inflammatory properties and reduce disease symptoms, in part, through suppression
of CD4+ T cell activation. Therefore, the Researchers' overall hypothesis is that dietary
supplementation with DHA and EPA in humans will ameliorate inflammatory symptoms, in part, by
suppressing CD4+ T cell activation, positively affecting muscle and cognitive function.
Inclusion criteria:
1. Healthy male or female according to the investigator/appointed staff judgment
2. 55 years and older
3. Stable body weight for the past 3 months (< 5% change)
Exclusion criteria:
1. History of cardiovascular disease
2. Metabolic diseases, including hepatic or renal disorders
3. Presence of acute illness or metabolically unstable chronic illness (including
diagnosis of Insulin Dependent Diabetes Mellitus)
4. Unwilling to stop taking nutritional supplements containing proteins or free amino
acids within 5 days of the first study day until study completion
5. Participated in a nutritional supplement study program within the past 4 weeks
6. Any other condition according to the PI or nurse that would interfere with the study
or safety of the subject or influence the results
7. Daily use of supplements containing > 1000 mg EPA+DHA 3 months prior to the first test
day
8. Known hypersensitivity to fish and/or shellfish, Swanson EFAs Super EPA Fish oil or
any of its ingredients, Swanson EFAs Certified Organic Extra Virgin Olive oil or any
of its ingredients
9. Presence of fever within the last 3 days
10. Failure to give informed consent
11. (Possible) Pregnancy
12. Unwilling to comply with any other rules set forth in the Informed Consent Form
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