Stool Microbiome, Pathogens, and Infectious Agents Among Olympic and Elite Athletes
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/30/2017 |
| Start Date: | June 3, 2016 |
| End Date: | March 21, 2017 |
TRMC-Bio "Molecular Profiling of Gut Microbiome, Microbiome Metabolome, Serum Chemistry, and Metabolism-Associated SNPs in Elite Athletes"
This research is being done to investigate fecal microbiome and metabolome as well as serum
analytes and single nucleotide polymorphisms in Olympic athletes in comparison with other
elite athletes.
analytes and single nucleotide polymorphisms in Olympic athletes in comparison with other
elite athletes.
Olympic athletes, non-Olympic elite athletes, and other active adults may have genetic and
metabolic profiles that are unique. These profiles may contribute to the caliber of their
athletic performance, and they may provide keys to understanding select genetic and metabolic
conditions.
Therefore, the specific aims of this project are as follows:
- Specific Aim 1: Characterize the fecal microbial communities in athletes participating
in the summer 2016 games and in athletes not participating in the Olympic games
- Specific Aim 2: Characterize the fecal microbiome metabolome (untargeted) in athletes
participating in the summer 2016 games and in athletes not participating in the Olympic
games
- Specific Aim 3: Characterize selected serum analytes and single nucleotide polymorphisms
(SNPs) of elite athletes participating in the Summer 2016 games and in athletes not
participating in the Olympic games, via serum and saliva analyses, respectively
- Specific Aim 4: Retain specimens from Olympic athletes participating in the summer 2016
games and in athletes not participating in the Olympic games for future research
- Specific Aim 7: Examine for the presence of Zika virus RNA in study participants who
exhibit symptoms
Stool, urine, and blood specimens will be collected to study the stool metabolome, as well as
serum analytes and single nucleotide polymorphisms, and the nature and extent of exposure to
pathogens and infectious agents. These will be compared between Olympic athletes and other
non-Olympic elite athletes.
metabolic profiles that are unique. These profiles may contribute to the caliber of their
athletic performance, and they may provide keys to understanding select genetic and metabolic
conditions.
Therefore, the specific aims of this project are as follows:
- Specific Aim 1: Characterize the fecal microbial communities in athletes participating
in the summer 2016 games and in athletes not participating in the Olympic games
- Specific Aim 2: Characterize the fecal microbiome metabolome (untargeted) in athletes
participating in the summer 2016 games and in athletes not participating in the Olympic
games
- Specific Aim 3: Characterize selected serum analytes and single nucleotide polymorphisms
(SNPs) of elite athletes participating in the Summer 2016 games and in athletes not
participating in the Olympic games, via serum and saliva analyses, respectively
- Specific Aim 4: Retain specimens from Olympic athletes participating in the summer 2016
games and in athletes not participating in the Olympic games for future research
- Specific Aim 7: Examine for the presence of Zika virus RNA in study participants who
exhibit symptoms
Stool, urine, and blood specimens will be collected to study the stool metabolome, as well as
serum analytes and single nucleotide polymorphisms, and the nature and extent of exposure to
pathogens and infectious agents. These will be compared between Olympic athletes and other
non-Olympic elite athletes.
Inclusion Criteria:
- Member of the Summer 2016 U.S. Olympic team and/or other elite athlete
- English speaking
- Willing to provide informed consent and biospecimens
- Willing to complete questionnaires regarding normal bowel habits and general health
Exclusion Criteria:
We found this trial at
1
site
Rochester, Minnesota 55905
Principal Investigator: Brent A Bauer, MD
Phone: 507-538-1887
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