Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB)

Inclusion Criteria:

- Informed consent: Subjects must give their signed and dated written informed consent
to participate prior to commencing any study related activities.

- Age Range: 12 to 50 years of age, inclusive, at Visit 1 (Screening).

- Diagnosis: A diagnosis of asthma, as defined by the National Institutes of Health for
at least 12 weeks prior to Visit 1.

- Asthma Severity: Subjects must have a pre-bronchodilator FEV1 of >=70 percent of the
predicted normal value. Predicted values will be based upon Global Lung Function
Initiative equations for spirometry reference values.

- Evidence of EIB: Subjects must answer "Yes" to at least 2 of the following 3 questions
reflecting on the previous 12 months:

- Are you short of breath during exercise or other physical exertion?

- Do you wheeze after exercise or other physical exertion?

- Do you cough after exercise or other physical exertion?

- Concurrent Anti-Asthma Therapy: Subjects must be taking low- to moderate dose inhaled
steroids for 12 weeks prior to Visit 1 in order to participate with no change in dose
for the 4 weeks prior to Visit 1.

- Gender: Subjects may be male or an eligible female. A female is eligible to enter and
participate in the study if she is of: Non-child bearing potential (i.e.,
physiologically incapable of becoming pregnant, including any female who is
post-menopausal or surgically sterile).Surgically sterile females are defined as those
with a documented hysterectomy and/or bilateral oophorectomy or tubal ligation.
Post-menopausal females are defined as being amenorrhoeic for greater than 1 year with
an appropriate clinical profile, e.g., age appropriate, > 45 years, in the absence of
hormone replacement therapy.

OR Child bearing potential, has a negative pregnancy test at screening, and agrees to
acceptable contraceptive methods approved in their local country, when used consistently
and correctly (i.e., in accordance with the approved product label and the instructions of
the physician for the duration of the study - screening to follow-up contact).

- Albuterol/salbutamol Use: All subjects must be able to replace their current
short-acting beta2-agonist with albuterol/salbutamol, to be used only on an as-needed
basis for the duration of the study. Each subject must be judged capable of
withholding albuterol/salbutamol for at least 6 hours prior to performing spirometric
evaluations.

- Physical Capacity: Each subject must be physically able to perform the exercise
challenges on a treadmill when bronchodilators have been withheld.

Exclusion Criteria:

- Intermittent Asthma, Seasonal Asthma, or Exercise-Induced Bronchoconstriction Only:
Subjects with only intermittent or seasonal asthma or only exercise-induced asthma are
excluded from participation in this study.

- History of Life-threatening Asthma: Defined for this protocol as an asthma episode
that required intubation and/or was associated with hypercapnia, respiratory arrest or
hypoxic seizures within the last 10 years.

- Asthma Exacerbation: Any asthma exacerbation requiring oral corticosteroids within 12
weeks of Visit 1 or that resulted in an overnight hospitalization requiring additional
treatment for asthma within 6 months prior to Visit 1.

- Symptomatic Allergic Rhinitis: Subjects with symptomatic allergic rhinitis at Visit 1
may be treated for up to four weeks with intranasal corticosteroids followed by a
repeat screening visit to determine eligibility prior to entry into the study.
Subjects that continue to be symptomatic after up to four weeks of treatment will be
excluded.

- 12-Lead Electrocardiogram (ECG): A subject is not eligible if he/she has an abnormal,
clinically significant ECG as determined by the investigator at the Screening Visit.

- Pregnancy: Women who are pregnant or lactating or are planning on becoming pregnant
during the study.

- Respiratory Infection: Culture-documented or suspected bacterial or viral infection of
the upper or lower respiratory tract, sinus or middle ear that is not resolved within
4 weeks of Visit 1 and led to a change in asthma management or, in the opinion of the
investigator, is expected to affect the subject's asthma status or the subject's
ability to participate in the study.

- Concurrent Respiratory Disease: A subject must not have current evidence of:

1. Atelectasis 2. Bronchopulmonary dysplasia 3. Chronic bronchitis 4. Chronic
obstructive pulmonary disease (COPD) (current or past diagnosis including asthma/COPD
overlap) 5. Pneumonia 6. Pneumothorax 7. Interstitial lung disease 8. Or any evidence
of concurrent respiratory disease other than asthma.

- Other Concurrent Diseases/Abnormalities: A subject must not have any clinically
significant, uncontrolled condition, or disease state that, in the opinion of the
investigator, would put the safety of the subject at risk through study participation
or would confound the interpretation of the efficacy results if the condition/disease
exacerbated during the study.

- Investigational Medications: A subject must not have used any investigational drug
within 30 days prior to Visit 1 or within five half-lives (t1/2) of the prior
investigational study, whichever is longer of the two periods.

- Allergies: 1) Drug Allergy: Any adverse reaction including immediate or delayed
hypersensitivity to any beta2-agonist, sympathomimetic drug, or any intranasal,
inhaled, or systemic corticosteroid therapy, or excipients used with FF/VI 100/25 or
FP 250 (i.e., drug, lactose or magnesium stearate). 2) Milk Protein Allergy: History
of severe milk protein allergy. 3) Latex Allergy: History of allergy or sensitivity to
latex that in the opinion of the investigator contraindicates the subject's
participation in the study.

- Concomitant Medication: Administration of prescription or non-prescription medication
that would significantly affect the course of asthma, or interact with study drug.

- Immunosuppressive Medications: A subject must not be using or require the use of
immunosuppressive medications during the study.

- Compliance: A subject will not be eligible if he/she or his/her parent or legal
guardian has any infirmity, disability, disease, or geographical location which seems
likely (in the opinion of the investigator) to impair compliance with any aspect of
this study protocol.

- Tobacco/Marijuana Use: Current tobacco smoker or has a smoking history of >=10
pack-years (20 cigarettes/day for 10 years). A subject may not have used inhaled
tobacco products or inhaled marijuana within the past 3 months (e.g. cigarettes,
cigars, electronic cigarettes, or pipe tobacco).

- Affiliation with Investigator's Site: A subject will not be eligible for this study if
he/she is an immediate family member of the participating investigator,
sub-investigator, study-coordinator or an employee of the participating investigator.