Bright 1 Bodies Weight Management Program
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 11 - 19 |
| Updated: | 6/1/2018 |
| Start Date: | July 2016 |
| End Date: | November 8, 2017 |
Bright 1 Bodies: Extending the Bright Bodies Weight Management Program to Adolescents With Type 1 Diabetes
Physical inactivity occurs among 65% to 95% of youth with type 1 diabetes (T1D) and based
upon limited evidence may contribute to the rapidly growing incidence of overweight among
this population. The purpose of the present study is to pilot test a 12-week intensive
lifestyle program for adolescents with overweight and T1D utilizing group exercise classes
adapted for this population, supplemented with coping skills training and diabetes
self-management education to address problem solving behaviors that limit their physical
activity and weight control. Our primary aim is to evaluate the changes in physical activity
adherence, anthropometrics, and self-management behaviors following this program among
sedentary adolescents with T1D and overweight (n=25, OW) compared with sedentary adolescents
with T1D and normal weight (n=25, NW). We hypothesize that the OW group will achieve improve
physical activity adherence and anthropometrics to the same or greater extent as the NW group
and previous Bright Bodies cohorts, and that these changes will correlate with improved
exercise-related problem solving. Our secondary aim is to evaluate changes in adipocytokines
and epigenetic factors related to the etiology of overweight/obesity following our physical
activity intervention. We hypothesize changes in these biomarkers will correlate with changes
in anthropometry variables and partially explain any differences in response between the
groups and individuals should those occur.
upon limited evidence may contribute to the rapidly growing incidence of overweight among
this population. The purpose of the present study is to pilot test a 12-week intensive
lifestyle program for adolescents with overweight and T1D utilizing group exercise classes
adapted for this population, supplemented with coping skills training and diabetes
self-management education to address problem solving behaviors that limit their physical
activity and weight control. Our primary aim is to evaluate the changes in physical activity
adherence, anthropometrics, and self-management behaviors following this program among
sedentary adolescents with T1D and overweight (n=25, OW) compared with sedentary adolescents
with T1D and normal weight (n=25, NW). We hypothesize that the OW group will achieve improve
physical activity adherence and anthropometrics to the same or greater extent as the NW group
and previous Bright Bodies cohorts, and that these changes will correlate with improved
exercise-related problem solving. Our secondary aim is to evaluate changes in adipocytokines
and epigenetic factors related to the etiology of overweight/obesity following our physical
activity intervention. We hypothesize changes in these biomarkers will correlate with changes
in anthropometry variables and partially explain any differences in response between the
groups and individuals should those occur.
Prevalence of overweight among patients with type 1 diabetes (T1D) of all ages has grown at
alarming rates since the 1980s. Physical inactivity occurs among 65% to 95% of youth with T1D
and doubles their risk of overweight. A major factor limiting their physical activity appears
to be self-managed problem solving around exercise such as adjustments to insulin and diet,
which is practiced regularly by less than half of our adolescent patients with T1D and less
frequently than any other self-management behavior. Our previous interventions applying
coping skills training (ABCs of Diabetes and TeenCope) as well as diabetes self-management
(Managing Diabetes) successfully improved problem-solving and other aspects of
self-management along with health outcomes among adolescents with T1D, but did not focus on
those who were overweight nor promotion of physical activity and weight loss. The Yale Bright
Bodies intensive lifestyle program successfully promotes physical activity and weight loss,
enrolling >100 overweight youth from greater New Haven annually but does not presently
accommodate those with T1D.
The purpose of the present study is to pilot test a 12-week intensive lifestyle program for
adolescents with overweight and T1D utilizing group exercise classes from Bright Bodies
adapted for this population, supplemented with coping skills training and diabetes
self-management education to address problem solving behaviors that limit their physical
activity and weight control. Our primary aim is to evaluate the changes in physical activity
adherence, anthropometrics (body mass index percentile for age, body fat percentage), and
self-management behaviors following this 12-week lifestyles program among sedentary
adolescents with T1D and overweight (n=25, OW) compared with sedentary adolescents with T1D
and normal weight (n=25, NW). We hypothesize that the OW group will achieve improve physical
activity adherence and anthropometrics to the same or greater extent as the NW group and
previous Bright Bodies cohorts, and that these changes will correlate with improved
exercise-related problem solving.
Although physical activity is recommended for weight loss, outcomes from increased physical
activity have been heterogeneously distributed—not all overweight participants lose weight
and some even gain weight. Furthermore the etiologies of overweight/obesity and T1D appear to
interact, yet no study has tested the influence of physical activity upon biological pathways
related to overweight/obesity for patients with T1D. Accordingly, our secondary aim is to
evaluate changes in adipocytokines and epigenetic factors related to the etiology of
overweight/obesity following our physical activity intervention. We hypothesize changes in
these biomarkers will correlate with changes in anthropometry variables and partially explain
any differences in response between the groups and individuals should those occur.
alarming rates since the 1980s. Physical inactivity occurs among 65% to 95% of youth with T1D
and doubles their risk of overweight. A major factor limiting their physical activity appears
to be self-managed problem solving around exercise such as adjustments to insulin and diet,
which is practiced regularly by less than half of our adolescent patients with T1D and less
frequently than any other self-management behavior. Our previous interventions applying
coping skills training (ABCs of Diabetes and TeenCope) as well as diabetes self-management
(Managing Diabetes) successfully improved problem-solving and other aspects of
self-management along with health outcomes among adolescents with T1D, but did not focus on
those who were overweight nor promotion of physical activity and weight loss. The Yale Bright
Bodies intensive lifestyle program successfully promotes physical activity and weight loss,
enrolling >100 overweight youth from greater New Haven annually but does not presently
accommodate those with T1D.
The purpose of the present study is to pilot test a 12-week intensive lifestyle program for
adolescents with overweight and T1D utilizing group exercise classes from Bright Bodies
adapted for this population, supplemented with coping skills training and diabetes
self-management education to address problem solving behaviors that limit their physical
activity and weight control. Our primary aim is to evaluate the changes in physical activity
adherence, anthropometrics (body mass index percentile for age, body fat percentage), and
self-management behaviors following this 12-week lifestyles program among sedentary
adolescents with T1D and overweight (n=25, OW) compared with sedentary adolescents with T1D
and normal weight (n=25, NW). We hypothesize that the OW group will achieve improve physical
activity adherence and anthropometrics to the same or greater extent as the NW group and
previous Bright Bodies cohorts, and that these changes will correlate with improved
exercise-related problem solving.
Although physical activity is recommended for weight loss, outcomes from increased physical
activity have been heterogeneously distributed—not all overweight participants lose weight
and some even gain weight. Furthermore the etiologies of overweight/obesity and T1D appear to
interact, yet no study has tested the influence of physical activity upon biological pathways
related to overweight/obesity for patients with T1D. Accordingly, our secondary aim is to
evaluate changes in adipocytokines and epigenetic factors related to the etiology of
overweight/obesity following our physical activity intervention. We hypothesize changes in
these biomarkers will correlate with changes in anthropometry variables and partially explain
any differences in response between the groups and individuals should those occur.
Inclusion Criteria:
- Patient of the Yale-New Haven Hospital (YNHH) Pediatrics Long Wharf or Trumbull
Diabetes Clinic
- Diagnosed with T1D
- 11 to 19 years old
- Sedentary (exercise less than twice per week over past two months)
- n=25 overweight (BMI > 85th percentile for age and sex according to Centers for
Disease Control Growth Charts) and n=25 normal weight
- Family willing to commit the time and effort to a family-based lifestyle program.
Exclusion Criteria:
- Endocrinopathies other than type 1 diabetes; adequately treated hypothyroidism, as
demonstrated by normal thyroid tests within previous six months, is allowed.
- Concurrent use of systemic (oral, parenteral) glucocorticoids or other medications
known to contribute to obesity; inhaled steroids are allowed.
- Any use of pharmacological intervention for weight management, including prescription
medication, over the counter medication, or herbal supplements.
- Chronic disease or physical disability that would influence treatment intervention or
preclude participation in regular physical activity (e.g., chronic renal failure).
- Psychological conditions such as uncontrolled eating disorder, psychosis, personality
disorders and other disorders that will interfere with the ability to maintain
complete follow up and adherence to protocol.
- Any concurrent membership in a comprehensive weight management program.
- Inability or unwillingness of the parent to accompany the child to nutrition classes.
- Pregnancy
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