Evaluation of Adults With Endocrine and Metabolic-Related Conditions
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 8/19/2018 |
| Start Date: | July 9, 2016 |
| End Date: | December 31, 2036 |
| Contact: | Karel Pacak, M.D. |
| Email: | karel@mail.nih.gov |
| Phone: | (301) 402-4594 |
Evaluation of Adults With Endocrine-Related Conditions
Background:
There are many endocrine and metabolic-related conditions. Two well-known disorders include
diabetes and thyroid disease. Some of these diseases are caused by a change in genes.
Researchers want to identify the genes involved in these disorders. They hope this will help
them learn more about these diseases.
Objectives:
To learn more about conditions that affect the hormone-secreting glands (endocrine glands) in
adults. To train doctors to diagnose and treat people with endocrine or metabolic conditions.
Eligibility:
Adults age 18 years and older with a known or suspected endocrine disorder.
Relatives ages 18 years and older.
Doctors will review all requests and available medical records to determine final eligibility
for the protocol.
Design:
Participants will have a medical history and physical exam.
Most participants will have 1 visit, and may have follow up visits if necessary. They may
have tests, surgery, or other procedures to help diagnose or treat their condition. These
could include:
- Blood, urine, and saliva tests
- Imaging tests. These may include X-ray, ultrasound, or scans.
- Sleep study
- Medical photographs
- Visits with other specialists at NIH
Participants will provide blood, urine, saliva, or tissue samples. Some of these samples may
be stored in the freezer for future studies.
Participants may be asked to participate in genetic testing. They will give a blood or saliva
sample for this.
There are many endocrine and metabolic-related conditions. Two well-known disorders include
diabetes and thyroid disease. Some of these diseases are caused by a change in genes.
Researchers want to identify the genes involved in these disorders. They hope this will help
them learn more about these diseases.
Objectives:
To learn more about conditions that affect the hormone-secreting glands (endocrine glands) in
adults. To train doctors to diagnose and treat people with endocrine or metabolic conditions.
Eligibility:
Adults age 18 years and older with a known or suspected endocrine disorder.
Relatives ages 18 years and older.
Doctors will review all requests and available medical records to determine final eligibility
for the protocol.
Design:
Participants will have a medical history and physical exam.
Most participants will have 1 visit, and may have follow up visits if necessary. They may
have tests, surgery, or other procedures to help diagnose or treat their condition. These
could include:
- Blood, urine, and saliva tests
- Imaging tests. These may include X-ray, ultrasound, or scans.
- Sleep study
- Medical photographs
- Visits with other specialists at NIH
Participants will provide blood, urine, saliva, or tissue samples. Some of these samples may
be stored in the freezer for future studies.
Participants may be asked to participate in genetic testing. They will give a blood or saliva
sample for this.
This protocol is designed to allow endocrine -related evaluations of adults with known or
suspected endocrine or metabolic disorders. Adults with endocrine or metabolic-related
condition(s) who may or may not be eligible for a specific NICHD research protocol, may be
evaluated under the auspices of this protocol to advance the clinical skills of physicians
participating in the Inter-Institute Internal Medicine Endocrine Fellowship Program (IIME)
clinical research and training programs, and to provide stimuli for new clinical research
initiatives. Standard medically-indicated laboratory or radiological studies may be performed
to confirm a diagnosis or to aid in the management of the patient. In some cases, the adult
participant may receive medical or surgical treatment for their disorder at the National
Institutes of Health (NIH) Clinical Center (CC) according to current clinical practice. The
overall purpose of endocrine evaluations under this protocol is to support our clinical
training and research missions.
suspected endocrine or metabolic disorders. Adults with endocrine or metabolic-related
condition(s) who may or may not be eligible for a specific NICHD research protocol, may be
evaluated under the auspices of this protocol to advance the clinical skills of physicians
participating in the Inter-Institute Internal Medicine Endocrine Fellowship Program (IIME)
clinical research and training programs, and to provide stimuli for new clinical research
initiatives. Standard medically-indicated laboratory or radiological studies may be performed
to confirm a diagnosis or to aid in the management of the patient. In some cases, the adult
participant may receive medical or surgical treatment for their disorder at the National
Institutes of Health (NIH) Clinical Center (CC) according to current clinical practice. The
overall purpose of endocrine evaluations under this protocol is to support our clinical
training and research missions.
- INCLUSION CRITERIA:
- Participants with known or suspected endocrine disorder age 18 years and older are
eligible for this protocol. Protocol investigators will make the actual selection of
patients most appropriate for clinical training.
- Relatives ages 18 years and older may be enrolled if clinically indicated for the
diagnosis of a proband.
EXCLUSION CRITERIA:
- Anyone under the age of 18 years old
- Any medical, physical, psychiatric, or social conditions, which, in the opinion of the
investigators, would make participation in this protocol not in the best interest of
the patient, will exclude participation. Patients who are critically ill, unstable, or
with severe organ failure that may affect/limit the endocrine evaluation and place
unsustainable demands on Clinical Center or NICHD resources will be excluded.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
301-496-2563
Phone: 800-411-1222
National Institutes of Health Clinical Center The National Institutes of Health (NIH) Clinical Center in...
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