An Observational Study of Presentation, Treatment Patterns, and Outcomes in Multiple Myeloma Participants

This is a prospective, non-interventional, observational study. This study will look at
contemporary, real-world patterns of patient characteristics, clinical disease presentation,
therapeutic regimen chosen, and clinical outcomes in participants with MM. Participants will
not be asked to change their routine clinical treatment. Participants will have to complete
patient reported outcomes (PROs) surveys during on-site routine office visits.

The study will enroll approximately 4200 participants. Participants will be assigned to one
of the following cohorts based upon the diagnosis of MM:

- ND MM within 3 months from initiation of treatment

- R/R MM who have received 1 to 3 prior lines of therapy

This multi-center trial will be conducted worldwide. The overall time to participate in this
study is up to 8 years. Participants will be evaluated and followed-up for a period of at
least 5 years, until death, are lost to follow-up, or the end of the study, whichever comes
first.

Inclusion Criteria:

Is 18 years of age or older.

Is experiencing the following:

1. Newly diagnosed MM within 3 months from initiation of treatment with documented month
and year of diagnosis, criteria met for diagnosis, stage, and MM-directed treatment
history, including duration, or

2. Relapsed/refractory MM who have received 1 to 3 prior lines of therapy with documented
data in the medical record regarding diagnosis (month and year), the regimens used in
1st, 2nd, and 3rd line as applicable, whether stem cell transplant was part of 1st,
2nd, and 3rd line of therapy, whether consolidation/maintenance was part of 1st, 2nd,
and 3rd line of therapy, also whether investigational therapy/treated on a clinical
trial was part of any of these regimens.

Is willing and able to sign informed consent to participate. Is willing and able to
complete patient-reported outcomes (PROs) in accordance with local regulatory and data
protection requirements.

Exclusion Criteria:

Is reporting to a site in this study for a second opinion (consultation only) or
participants whose frequency of consult and follow-up are not adequate for quarterly
electronic case report form (eCRF) completion.

Has participated in another study (observational or interventional) that prohibits
participation in this study.