Safety and Efficacy of AVP-923 for Pseudobulbar Affect in Multiple Sclerosis Patients
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 68 |
| Updated: | 7/15/2016 |
| Start Date: | December 2002 |
| End Date: | June 2004 |
Pseudobulbar Affect is a condition characterized by frequent episodes of laughing and crying
out of proportion. Other terms used to describe this condition include emotional lability,
emotionalism, emotion incontinence, emotional discontrol, excessive emotionalism and
pathological laughing and crying. AVP-923 is a new experimental drug that may assist in the
reduction of uncontrolled episodes. This study will test the safety and efficacy of AVP-923
in the treatment of MS patients suffering from pseudobulbar affect.
out of proportion. Other terms used to describe this condition include emotional lability,
emotionalism, emotion incontinence, emotional discontrol, excessive emotionalism and
pathological laughing and crying. AVP-923 is a new experimental drug that may assist in the
reduction of uncontrolled episodes. This study will test the safety and efficacy of AVP-923
in the treatment of MS patients suffering from pseudobulbar affect.
Inclusion Criteria:
- 18 to 68 years of age
- Confirmed diagnosis of Multiple Sclerosis
- Clinical history of pseudobulbar affect
Exclusion Criteria:
- Sensitivity to quinidine or opiate drugs
- Recent diagnosed within 2 months with Multiple Sclerosis
- Patient on anti-depressants
- Patient with liver or kidney disease
- Patient with hypotension
We found this trial at
20
sites
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