Safety and Efficacy of Dextromethorphan and Quinidine in the Treatment of the Pain of Diabetic Neuropathy

Inclusion Criteria:

- Diagnosis of diabetes mellitus

- Established diabetic therapy for at least 3 months

- Lab-supported diagnosis of painful diabetic distal symmetric sensory/motor
polyneuropathy

- Pain the previous three months

- Not pregnant

Exclusion Criteria:

- Patient failed adequate trial of 3 or more medications or has required narcotics for
pain

- History of torsades de pointes

- Sensitivity to quinidine or opiate drugs (codeine, etc)

- Severe pain that could confound the assessment

- Patient has had any amputations

- Patient has participated in the past 30 days or is currently participating in another
trial

- Patient has previously received treatment with dextromethorphan and quinidine