The Healthy Cookie Study: Understanding How Healthy Cookies Affect Fat in the Blood,
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 7/23/2016 |
| Start Date: | January 2016 |
| End Date: | December 2017 |
| Contact: | Martha M Belury, Ph.D. RD |
| Email: | belury.1@osu.edu |
| Phone: | 614-292-1680 |
The purpose of this study is to understand how consuming healthy cookies every day for two
weeks will affect different types of fat in the blood. Specifically, the overall goal of
this study is to find out if the healthy cookies can increase a polyunsaturated fat called
linoleic acid in plasma, red blood cells and white blood cells.
weeks will affect different types of fat in the blood. Specifically, the overall goal of
this study is to find out if the healthy cookies can increase a polyunsaturated fat called
linoleic acid in plasma, red blood cells and white blood cells.
Overall, linoleic acid has many health benefits including altering body composition and
energy metabolism, possibly through its impact on cardiolipin. It is therefore imperative to
develop foods products that allow for Americans to easily increase their intake of linoleic
acid. It's also important to understand the mechanism in which linoleic acid exerts these
positive health effects, particularly in states of muscle mass and quality loss associated
with mitochondria dysfunction.
The investigators plan to test the central hypothesis and accomplish the overall objective
of this research by pursuing the following three specific aims
Aim 1: To determine the extent to which cookies, made with grapeseed oil , increase linoleic
acid in plasma, red blood cells (RBCs), and peripheral blood mononuclear cells (PBMCs)
fraction of blood after two weeks consumption
Aim 2: To determine the extent to which cookies, made with grapeseed oil, increase
cardiolipin and linoleic acid content of cardiolipin in PBMCs after two weeks of consumption
Aim 3: To determine and compare the acceptability of consuming cookies made with grapeseed
oil or high oleic safflower oil every day for two weeks
energy metabolism, possibly through its impact on cardiolipin. It is therefore imperative to
develop foods products that allow for Americans to easily increase their intake of linoleic
acid. It's also important to understand the mechanism in which linoleic acid exerts these
positive health effects, particularly in states of muscle mass and quality loss associated
with mitochondria dysfunction.
The investigators plan to test the central hypothesis and accomplish the overall objective
of this research by pursuing the following three specific aims
Aim 1: To determine the extent to which cookies, made with grapeseed oil , increase linoleic
acid in plasma, red blood cells (RBCs), and peripheral blood mononuclear cells (PBMCs)
fraction of blood after two weeks consumption
Aim 2: To determine the extent to which cookies, made with grapeseed oil, increase
cardiolipin and linoleic acid content of cardiolipin in PBMCs after two weeks of consumption
Aim 3: To determine and compare the acceptability of consuming cookies made with grapeseed
oil or high oleic safflower oil every day for two weeks
Inclusion Criteria:
- Nonsmokers
Exclusion Criteria:
- Current or previous diagnosis of diabetes, heart (including stroke or heart attack),
kidney, liver or circulatory diseases and/or current treatment for cancer.
- Gastrointestinal diseases or disorders (including pancreatic) or gastric bypass
surgery
- Food Allergy or Intolerance & Bee allergy
- Any dietary restriction where consumption of these healthy cookies or any ingredient
would be contraindicated
- Use of medications where consuming the healthy cookies would be contraindicated
- Use of supplements/oils high in linoleic acid in the past 4 weeks prior to enrolling
- Pregnancy
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