Dietary Prevention of Photodamage in Skin With Grapes

To determine whether oral grape powder will result in a reduction in biomarkers associated
with basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs). Biomarkers taken from
non-sun-exposed skin and UV-exposed skin before and after treatment will be compared.

The ultimate goal of this study will be to generate new knowledge of the photoprotective
effect of grape powder on UV exposure. The results may be employed as the basis for a larger
clinical trial to evaluate the potential of grapes to prevent non-melanoma skin cancers
(NMSCs) and sun damage.

Inclusion Criteria:

- Patient age 18 and older

- Patient able to understand requirements of the study and risks involved

- Patient able to sign a consent form

Exclusion Criteria:

- Patients Fitzpatrick IV-VI

- A recent history of vitiligo, melasma, and other disorders of pigmentation with the
exception of post inflammatory hyperpigmentation

- A known history of photosensitivity disorders

- A known history of melanoma or non-melanoma skin cancers

- Those planning on going to the tanning parlors

- Using any of the photosensitizing medication

- A woman who is lactating, pregnant, or planning to become pregnant

- Patient planning on exposing the irradiated or control areas to the sun