Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/30/2016 |
| Start Date: | February 2005 |
| End Date: | May 2009 |
Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus
Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients,
who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV.
Two medicines have been reported to suppress nystagmus and improve vision in such patients:
gabapentin and memantine. The investigators set out to test which of these two drug was more
effective by carrying out a double-blind cross-over study. In this way, we could determine
which drug worked best in each patient.
who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV.
Two medicines have been reported to suppress nystagmus and improve vision in such patients:
gabapentin and memantine. The investigators set out to test which of these two drug was more
effective by carrying out a double-blind cross-over study. In this way, we could determine
which drug worked best in each patient.
The study entails careful measurements of visual acuity and precise measurements of eye
movements, using a contact lens device (magnetic search coil method). In this way, it is
possible to make objective and reliable measurements of the effect of each drug, which are
unbiased by the investigator or the patient.
movements, using a contact lens device (magnetic search coil method). In this way, it is
possible to make objective and reliable measurements of the effect of each drug, which are
unbiased by the investigator or the patient.
Inclusion Criteria:
- Adult (18 years or older) males or females with acquired nystagmus that is degrading
their vision
Exclusion Criteria:
- Pregnant women
- Individuals who cannot describe their visual symptoms, cooperate with testing, or
give informed consent
- Individuals with intolerance of gabapentin or memantine
We found this trial at
1
site
Click here to add this to my saved trials
