Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1

Key Inclusion Criteria:

- Urinary Incontinence for at least 3 months prior to Screening as a result of
Neurogenic Detrusor Overactivity due to Spinal Cord Injury or Multiple Sclerosis.

- Subjects with Spinal Cord Injury must have a stable neurological injury at T1 level or
below which occurred at least 6 months prior to Screening.

- Subjects with Multiple Sclerosis must be clinically stable in the investigator's
opinion, with no exacerbation (relapse) of MS for at least 3 months prior to
Screening.

- Subjects must have had an inadequate response after at least 4 weeks of oral
medications used in the treatment of NDO (e.g. anticholinergics, beta-3 agonists)
and/or have intolerable side-effects.

- Routinely performing Clean Intermittent Catheterization (CIC) to ensure adequate
bladder emptying.

- An average of at least two episodes per day of Urinary Incontinence recorded on the
screening bladder diary.

Key Exclusion Criteria:

- Any current condition (other than NDO) that may impact on bladder function.

- Previous or current, tumour or malignancy affecting the spinal column or spinal cord,
or any other unstable cause of SCI.

- Any condition that will prevent cystoscopic treatment administration or CIC usage,
e.g. urethral strictures.

- Current indwelling bladder catheter, or removal of indwelling bladder catheter less
than 4 weeks prior to Screening.

- BTX-A treatment within 9 months prior to Screening for any urological condition (e.g.
detrusor or urethral sphincter treatments).

- Any neuromodulation/electrostimulation usage for urinary symptoms/incontinence within
4 weeks prior to Screening. Any implanted neuromodulation device must be switched off
at least 4 weeks prior to Screening.