A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction

Inclusion Criteria:

• Men or women, at least 18 years of age, with evidence of moderate renal impairment (an
eGFR ≥ 30 and <60 mL/min/1.73 m2) and myocardial necrosis in a clinical setting consistent
with a type I (spontaneous) acute myocardial infarction (AMI).

Exclusion Criteria:

- Symptoms, biomarker elevation or electrocardiogram (ECG) changes other than those of
the index event that are consistent with a diagnosis of AMI but are likely not due to
primary myocardial ischemia

- Ongoing hemodynamic instability

- Planned coronary artery bypass surgery

- Evidence of hepatobiliary disease

- History of acute kidney injury (AKI) after previous exposure to an intravenous
contrast agent.

- History of nephrotic range proteinuria.

- Known history of allergy to soy beans or peanuts, immunoglobulin A (IgA) deficiency,
antibodies to IgA , or hypersensitivity to CSL112 or any of its components.

- Other severe comorbid condition, concurrent medication, or other issue that renders
the subject unsuitable for participation in the study.