Bladder Environment: Microbiome Oxygen Relationship
| Status: | Completed |
|---|---|
| Conditions: | Overactive Bladder, Urology |
| Therapuetic Areas: | Gastroenterology, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/22/2018 |
| Start Date: | June 2, 2016 |
| End Date: | August 17, 2017 |
The purpose of this study is to characterize bladder urinary oxygen tension (BUOT) in women
whose urinary microbiomes contains at least one anaerobic bacterial species versus women
whose urinary microbiomes do not contain anaerobes.
whose urinary microbiomes contains at least one anaerobic bacterial species versus women
whose urinary microbiomes do not contain anaerobes.
Throughout the human body, microbial communities (microbiota) depend on their environment,
including the level of oxygen (anaerobic vs. aerobic). Recently published evidence documents
the existence of a female urinary microbiota (FUM) and provides evidence that the FUM differ
based on lower urinary tract symptoms, i.e. no bladder symptoms, urgency urinary
incontinence, and urinary tract infection1-4. Members of the FUM include bacteria that
require oxygen (aerobes), those that abhor oxygen (anaerobes) and those that thrive in both
conditions (facultative anaerobes)5. This last group of microbes is known to consume low
levels of oxygen to maintain an anaerobic environment. Yet, virtually nothing is known about
oxygen levels in bladder urine even though bladder urine oxygen tension may both affect and
be affected by the FUM. Given the role oxygen levels play in other parts of the human body,
the investigators request resources to investigate bladder urine oxygen levels. The study is
designed to understand if BUOT levels differ in FUMs with and without at least one anaerobe,
and if so, if there are any patient factors or urinary symptoms associated with certain BUOT
including the level of oxygen (anaerobic vs. aerobic). Recently published evidence documents
the existence of a female urinary microbiota (FUM) and provides evidence that the FUM differ
based on lower urinary tract symptoms, i.e. no bladder symptoms, urgency urinary
incontinence, and urinary tract infection1-4. Members of the FUM include bacteria that
require oxygen (aerobes), those that abhor oxygen (anaerobes) and those that thrive in both
conditions (facultative anaerobes)5. This last group of microbes is known to consume low
levels of oxygen to maintain an anaerobic environment. Yet, virtually nothing is known about
oxygen levels in bladder urine even though bladder urine oxygen tension may both affect and
be affected by the FUM. Given the role oxygen levels play in other parts of the human body,
the investigators request resources to investigate bladder urine oxygen levels. The study is
designed to understand if BUOT levels differ in FUMs with and without at least one anaerobe,
and if so, if there are any patient factors or urinary symptoms associated with certain BUOT
Inclusion Criteria:
- Age > 18
- No indwelling urethral catheter
- At least 50 mL of urine in their bladder as determined by the clinic's bladder scanner
Exclusion Criteria:
- Non-English speaker
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