Impact of Transcranial Direct Current Stimulation on Fatigability and Fatigue Induced by a Selective Attention Task
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 8/20/2016 |
| Start Date: | July 2015 |
| Contact: | Benzi Kluger, MD |
| Email: | benzi.kluger@ucdenver.edu |
| Phone: | 303-724-4400 |
This research project is focusing on changes in mental fatigue due to transcranial direct
current stimulation (tDCS) in healthy individuals. The study aim is to see if mental fatigue
can be rescued by administering a safe dose of tDCS. tDCS has been shown to decrease fatigue
in healthy individuals experiencing extended wakefulness, and the investigators aim to
investigate if similar results can be found in a fatigue inducing task. This is a
single-blind randomized control trial that will compare mental fatigue between tDCS
treatment and sham treatment groups through both subjective and objective measures.
Objective fatigue will be measured by reaction time with the Stroop test and subjective
fatigue will be measured by the multidimensional fatigue inventory questionnaire.
current stimulation (tDCS) in healthy individuals. The study aim is to see if mental fatigue
can be rescued by administering a safe dose of tDCS. tDCS has been shown to decrease fatigue
in healthy individuals experiencing extended wakefulness, and the investigators aim to
investigate if similar results can be found in a fatigue inducing task. This is a
single-blind randomized control trial that will compare mental fatigue between tDCS
treatment and sham treatment groups through both subjective and objective measures.
Objective fatigue will be measured by reaction time with the Stroop test and subjective
fatigue will be measured by the multidimensional fatigue inventory questionnaire.
Right handed healthy individuals aged 18-40 will be eligible to participate. Participants
will be randomized in a 1:1:1 ratio to receive real or placebo 2mA tDCS delivered for 20
minutes while performing a 3 hour computerized cued Stroop task. Groups will receive real or
sham stimulation during the first 20 minutes or 90-110 minutes into the task. Groups will
be: 1) Sham (sham given at both time points); 2) Prevent (real will be given during first 20
minutes to try to prevent or delay fatigue and sham given at second time point); or 3)
Rescue (sham will be given initially and real given at 90-110 minutes to see if performance
can be rescued after fatigue has set in). The primary outcome measure will be the slope of
change for intra-individual variability of response time for correct items and regression
models will be used to determine whether real preventative or rescue tDCS alters the rate of
performance change relative to sham stimulation. Accuracy and mean response time will also
be examined as secondary outcomes.
will be randomized in a 1:1:1 ratio to receive real or placebo 2mA tDCS delivered for 20
minutes while performing a 3 hour computerized cued Stroop task. Groups will receive real or
sham stimulation during the first 20 minutes or 90-110 minutes into the task. Groups will
be: 1) Sham (sham given at both time points); 2) Prevent (real will be given during first 20
minutes to try to prevent or delay fatigue and sham given at second time point); or 3)
Rescue (sham will be given initially and real given at 90-110 minutes to see if performance
can be rescued after fatigue has set in). The primary outcome measure will be the slope of
change for intra-individual variability of response time for correct items and regression
models will be used to determine whether real preventative or rescue tDCS alters the rate of
performance change relative to sham stimulation. Accuracy and mean response time will also
be examined as secondary outcomes.
Inclusion Criteria:
- right-handed
- normal or corrected-normal vision,
Exclusion Criteria:
- pregnant women,
- history of medical conditions associated with fatigue, including, but not limited to:
- Parkinson's disease,
- Alzheimer's disease,
- diabetes mellitus,
- hypothyroidism,
- chronic fatigue syndrome,
- anemia,
- infectious mononucleosis,
- irritable bowel syndrome
We found this trial at
1
site
13001 E. 17th Pl
Aurora, Colorado 80045
Aurora, Colorado 80045
303-724-5000
Phone: 303-724-4644
University of Colorado Denver The University of Colorado Denver | Anschutz Medical Campus provides a...
Click here to add this to my saved trials
