A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer

Inclusion Criteria:

- Have advanced or metastatic cancer (solid tumors) and be an appropriate candidate for
experimental therapy.

- Part B: Have advanced or metastatic cancer with an activating mitogen-activated
protein kinase pathway alteration, BRAF mutant metastatic melanoma refractory to
or relapsed after treatment with RAF and/or MEK inhibitors, metastatic melanoma
with an NRAS mutation, BRAF mutant NSCLC.

- Part C: Advanced, unresectable cancer (dose escalation) and advanced,
unresectable, or metastatic non-small cell lung cancer with a BRAF or RAS
mutation, and colorectal cancer with a RAS mutation and advanced or metastatic
cancer with an activating mitogen activated protein kinase pathway alteration
(dose expansion).

- Part D: Have metastatic pancreatic ductal adenocarcinoma (dose escalation and
dose expansion).

- Have discontinued previous treatments for cancer and have resolution, except where
otherwise stated in the inclusion criteria, of all clinically significant toxic
effects of prior chemotherapy, surgery, or radiotherapy to Grade ≤1 by National Cancer
Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE), Version 4.0.

- Have adequate organ function.

- Have a performance status of 0 to 1 on the Eastern Cooperative Oncology Group (ECOG)
scale.

Exclusion Criteria:

- Have serious preexisting medical conditions.

- Have a known human immunodeficiency virus (HIV) infection or known
activated/reactivated hepatitis A, B, or C.

- Have symptomatic central nervous system malignancy or metastasis.

- Have current hematologic malignancies, acute or chronic leukemia.

- Have a second primary malignancy that in the judgment of the investigator or Lilly may
affect the interpretation of results.

- Have prior malignancies. Participants with carcinoma in situ of any origin and
participants with prior malignancies who are in remission and whose likelihood of
recurrence is very low, as judged by the Lilly clinical research physician, are
eligible for this study.

- Have a mean QT interval corrected for heart rate (QTc) of ≥470 milliseconds on
screening electrocardiogram (ECG) as calculated using the Bazett's formula at several
consecutive days of assessment.

- Have participated, within the last 28 days in a clinical trial involving an
investigational product or are currently enrolled in a clinical trial involving an
investigational product or any other type of medical research judged not to be
scientifically or medically compatible with this study.

- Have previously completed or withdrawn from this study or any other study
investigating an ERK1/2 inhibitor.

- If female, is pregnant, breastfeeding, or planning to become pregnant.

- Have history or findings of central or branch retinal artery or venous occlusion with
significant vision loss or other retinal diseases that cause current visual impairment
or would likely cause visual impairment over the time period of the study.

- Currently using concomitant medications that are strong inhibitors or inducers of
CYP3A4.