A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic Cancer



Status:Completed
Conditions:Lung Cancer, Colorectal Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/16/2018
Start Date:August 10, 2016
End Date:May 15, 2017

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A Phase 1 Dose-Escalation Study of LY2606368 in Combination With Ralimetinib in Patients With Advanced or Metastatic Cancer

The main purpose of this study is to evaluate the safety of the study drug prexasertib in
combination with ralimetinib in participants with advanced or metastatic cancer.


Inclusion Criteria:

- Advanced or metastatic cancer.

- Able to swallow tablets.

- For Part B, you will need to have colon cancer or non-small cell lung (NSCLC) cancer
with KRAS and/or BRAF mutations.

- Discontinued all previous treatments for cancer and recovered from the acute effects
from the therapy.

Exclusion Criteria:

- Active infection (fungal, viral, or bacterial).

- Active cancer in your brain or spinal cord.

- Acute or chronic leukemia.

- Serious heart condition.

- Disease that requires immunosuppressant therapy.

- Diagnosis of inflammatory bowel disease.

- Major small bowel resection that interferes with your body's ability to absorb the
oral medicine.

- Participated in other clinical trials investigating prexasertib or ralimetinib.

- Pregnant or breastfeeding.

- Other pre-existing conditions or medical history which your doctor will explain to
you.
We found this trial at
3
sites
1100 H Street Northwest
Köln, 50937
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Köln,
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1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
Principal Investigator: Jimmy Hwang
Phone: 980-442-2000
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Charlotte, NC
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Nashville, Tennessee 37203
Principal Investigator: SMO Sarah Cannon Research Inst.
Phone: 615-329-7615
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Nashville, TN
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