Effect of a Proprietary Dietary Supplement on Fecal Volatile Organic Compounds

Inclusion Criteria:

- Male or female of any race or ethnicity between 18 to 70 years of age, inclusive;

- Body mass index (BMI) between 20 - 32 inclusive;

- Non-smoking status;

- Willing to consume assigned dietary supplements for a total of 6 weeks;

- Have access to email and a digital camera or camera phone.

Exclusion Criteria:

- Age <18 or >70 years;

- BMI <20 or >32;

- Uncontrolled hypertension defined as diastolic blood pressure ≥95 mm Hg or systolic
blood pressure ≥160 mm Hg;

- Self-reported presence of atherosclerotic disease and/or cardiopulmonary disease;

- Renal, hepatic, endocrine, gastrointestinal or other systemic disease;

- For women, pregnancy, breast feeding or postpartum less than 6 months;

- Current participation in another research study;

- Allergy to the components in the dietary supplement (inulin, fructooligosaccharide,
blueberries, black currant, rice);

- History of drug or alcohol abuse;

- Use of antibiotics within the last 6 months;

- Use of prebiotics or flavonoid-containing dietary supplements within the last 30
days;

- Multiple food allergies or significant food preferences or restrictions that would
interfere with diet adherence;

- Chronic use of over-the-counter medication which would interfere with study endpoints
including NSAIDS, laxatives and antacids;

- Participating in or planning to begin a weight loss diet during the study period;

- Lifestyle or schedule incompatible with the study protocol;

- Other medical, psychiatric, or behavioral conditions that in the view of the
principal investigator may present a safety hazard to the participant or interfere
with study participation or the ability to follow the intervention protocol;

- Use of tobacco products.