Let's Play! Healthy Kids After Cancer

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, accounting for 25% of
all childhood malignancies. Treatment of childhood ALL has a high success rate, with
long-term event-free survival of >85%. Treatment success, however, has not come without cost.
Recognition of long-term health problems related to childhood cancer therapies is growing.
Both during and after therapy, children treated for ALL are at risk for fatigue, reduced
physical activity, poor dietary intake, and excessive weight gain, which are driven by
physiological (chemotherapy-induced) changes and social (home/environmental) factors. The
goals of this pilot study are to evaluate the feasibility, acceptability, and potential
efficacy of a parent-targeted, phone-delivered nutrition and physical activity program to
prevent unhealthy weight gain among 60 childhood ALL survivors, 4-10 years of age.
Participants will be randomly assigned to either the phone-delivered parent-targeted
nutrition and physical activity intervention or a standard-of-care control group.
Intervention success will be benchmarked by changes in key weight-related behaviors (physical
activity and dietary intake) over the 6-month trial, and initial impact of the intervention
on biomarkers of inflammation and oxidative stress, fatigue, and body composition will be
examined.

Inclusion Criteria:

- Between 4.0 years and < 11.0 years of age at the time of recruitment

- Previously diagnosed of ALL and currently in remission

- Between 1-5 years post completion of chemotherapy

- BMI ≥ 85 percentile for age and sex (overweight or obese) OR at risk for obesity (BMI
between the 50th and 85th percentile and at least one overweight parent (BMI ≥ 25
kg/m2)

Exclusion Criteria:

- History of cranial radiation therapy

- History of bone marrow transplant

- History of relapse of ALL

- Diagnosis of Down's Syndrome

- Comorbidities of obesity that require immediate subspecialist referral

- Significant pulmonary, cardiovascular, orthopedic, or musculoskeletal problems that
would, in their oncologist's judgment, limit their ability to participate in physical
activity

- Significant psychiatric or neurologic disorders that would impair compliance with
study protocol

- Current participation in a weight-loss program