Oral Carnitine for Cramps in Pregnancy

Muscle cramps occur frequently among pregnant women, and few therapeutic options exist. This
is a study of oral L-carntine, a dietary supplement, for the treatment of muscle cramps in
pregnancy. The conceptual basis for this study comes from the fact that carnitine has been
used effectively in multiple randomized trials for the treatment of muscle cramps in other
carnitine deficient states (such as hemodialysis). In pregnancy, women have decreased serum
carnitine concentrations (from decreased intake, increased clearance by the kidney, and
increased demands from the fetus). Thus, our hypothesis is that carnitine will alleviate or
eliminate muscle cramps experienced by pregnant women.

Inclusion Criteria:

- Age 16 or older

- Gestational Age 12 to 33 weeks

- Occurrence of muscle cramps at least once weekly

- Ability to tolerate oral L-Carnitine

- Ability / willingness to provide informed consent in English or Spanish

Exclusion Criteria:

- Prior treatment for muscle cramps during this pregnancy

- Chronic muscle cramps prior to pregnancy

- Magnesium administration beyond that contained in prenatal vitamins

- History of seizures

- History of Pre-term delivery before 36 weeks gestational age

- Inability to tolerate oral L-Carnitine (e.g. hyperemesis gravidarum)

- Inability or unwillingness to provide informed consent