Measurement of FeNO in Young Children With the NIOX VERO
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Asthma, Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 4 - 6 |
| Updated: | 11/16/2017 |
| Start Date: | January 2016 |
| End Date: | May 31, 2017 |
A Randomized, Multi-Center, Single-Visit, Clinical Investigation to Assess the Degree of Agreement and Feasibility of Measuring Exhaled Nitric Oxide in Children, Aged 4-6 Years Old, With the NIOX VERO Using the 6 Second Exhalation Mode as Compared With the 10 Second Exhalation Mode
FeNO measurements provide the physician with means of evaluating an asthma patient's response
to anti-inflammatory therapy, as an adjunct to the established clinical and laboratory
assessments in asthma. Interpretation of FeNO profiles is based on the nitric oxide plateau.
To achieve plateau, the duration of exhalation must be sufficient (at least 4 seconds for
children <12 years and > 6 seconds for children > 12 years (ATS/ERS, 2005).
Measurement of FeNO using the 6-sec mode may provide a viable alternative in children as
young as age 4 years who may have difficulty maintaining exhalation for a full 10 seconds.
to anti-inflammatory therapy, as an adjunct to the established clinical and laboratory
assessments in asthma. Interpretation of FeNO profiles is based on the nitric oxide plateau.
To achieve plateau, the duration of exhalation must be sufficient (at least 4 seconds for
children <12 years and > 6 seconds for children > 12 years (ATS/ERS, 2005).
Measurement of FeNO using the 6-sec mode may provide a viable alternative in children as
young as age 4 years who may have difficulty maintaining exhalation for a full 10 seconds.
The primary objective is to assess the degree of agreement of FeNO measured with the NIOX
VERO using the 6-sec and 10-sec modes.
The secondary objectives of the Clinical Investigation are to:
- Assess the ability of participants to use the NIOX VERO for measuring FeNO in both
exhalation modes, and
- Compare the repeatability of FeNO measured with the NIOX VERO in both exhalation modes.
Participants will attempt 2 measurements taken using the 6-sec mode followed by 2
measurements using the 10 second exhalation mode or vice versa.
VERO using the 6-sec and 10-sec modes.
The secondary objectives of the Clinical Investigation are to:
- Assess the ability of participants to use the NIOX VERO for measuring FeNO in both
exhalation modes, and
- Compare the repeatability of FeNO measured with the NIOX VERO in both exhalation modes.
Participants will attempt 2 measurements taken using the 6-sec mode followed by 2
measurements using the 10 second exhalation mode or vice versa.
Inclusion Criteria:
1. Male or female 4, 5 and 6 years old,
2. Primary Language: English or Spanish, and
3. Healthy (e.g., no pulmonary disease) or Asthmatic (if asthmatic, they must have a
physician diagnosis of asthma).
Exclusion Criteria:
1. Pulmonary Disease Status: Any disease other than asthma.
2. In the opinion of the investigator, has severe or uncontrolled asthma (defined as
having a) 2 or more exacerbations within the last year that required the use of
systemic corticosteroids, or b) 1 or more hospitalizations, ICU stays or mechanical
ventilations within the last year).
3. Has taken their reliever inhaler within 4 - 6 hours from the FeNO measurements.
4. Has acute asthma symptoms, respiratory illness (e.g. cold, flu), or sinusitis.
5. Has had food or beverage intake (other than water) or has participated in strenuous
exercise within 1 hour prior to FeNO measurement.
6. Has a family relationship with the Operator or Study Personnel (persons who are family
members of the Operator or Study Personnel are not eligible to participate).
7. Has a Parent/Guardian who is unable or unwilling to provide informed consent.
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