A Phase I Study to Assess the Pharmacokinetics of GSK2798745 Tablets

Inclusion Criteria:

- Between 18 and 75 years of age inclusive, at the time of signing the informed consent

- Healthy as determined by the investigator or medically qualified designee based on a
medical evaluation including medical history, physical examination, laboratory tests
and cardiac monitoring. A subject with a clinical abnormality or laboratory
parameter(s) which is/are not specifically listed in the inclusion or exclusion
criteria, outside the reference range for the population being studied may be
included only if the investigator in consultation with the Medical Monitor if
required agree and document that the finding is unlikely to introduce additional risk
factors and will not interfere with the study procedures

- Body weight >=50 kg and body mass index within the range 18 - 32 kilogram (kg)/meter
(m)^2 (inclusive)

- Male or female of non-child bearing potential:

A male subject with a female partner of child bearing potential is eligible to participate
if he agrees to use contraception as mentioned in the protocol during the treatment period
and for at least 7 days after the last dose of study treatment and refrain from donating
sperm during this period A female subject is eligible to participate if she is not a woman
of childbearing potential (WOCBP) as defined in the protocol.

- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the consent form and in this protocol

Exclusion Criteria:

- History of acute coronary syndromes including unstable angina or myocardial
infarction within 6 months of screening

- History of stroke or seizure disorder within 5 years of Screening

- Active ulcer disease or gastrointestinal bleeding at the time of screening

- Alanine transaminase (ALT) and bilirubin >1.5x Upper limit of normal (ULN) is
acceptable if bilirubin is fractionated and direct bilirubin <35%)

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones)

- QT interval corrected according to Fridericia's formula (QTcF) >450 milliseconds
(msec)

- History or current evidence of any serious or clinically significant
gastrointestinal, renal, endocrine, neurologic, hematologic or other condition that
is uncontrolled on permitted therapies or that would, in the opinion of the
investigator or the Medical Monitor, make the subject unsuitable for inclusion in
this study

- Urinary cotinine levels indicative of current smoking or regular use of tobacco- or
nicotine-containing products at time of screening (cotinine levels >200 nanogram
[ng]/millimeter [mL])

- History of alcohol abuse within 6 months of the study based on the following
criteria:

An average weekly intake of >14 drinks for males or >7 drinks for females. One drink is
equivalent to 12 g of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of wine or
1.5 ounces (45 mL) of 80 proof distilled spirits

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or Medical
Monitor, contraindicates their participation

- Presence of hepatitis B surface antigen, positive hepatitis C antibody test result at
screening or within 3 months of screening.

- A positive test for human immunodeficiency virus antibody

- A positive pre-study drug/alcohol screen

- A screening cardiac Troponin level > ULN

- Use of another investigational product in a clinical study within the following time
period prior to the first administration of study medication in the current study: 30
days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer)

- Exposure to more than 4 investigational medicinal products within 12 months prior to
the first administration of study medication.

- Unable to refrain from the use of prescription or non-prescription drugs (including
vitamins and dietary or herbal supplements) except permitted medications listed in
the protocol, within 7 days (or 14 days if the drug is a potential enzyme inducer) or
5 half-lives (whichever is longer) prior to the first dose of study medication until
completion of the follow-up visit, unless in the opinion of the Investigator and/ or
sponsor the medication will not interfere with the study.