Brain Blood Flow: Age and Gender
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies, Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 20 - 64 |
| Updated: | 1/13/2019 |
| Start Date: | August 2016 |
| End Date: | August 2019 |
| Contact: | Jill N Barnes, PhD |
| Email: | jnbarnes@wisc.edu |
| Phone: | 608-262-1654 |
Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex
Baseline cerebral blood flow through the middle cerebral artery (MCA) and cerebral
vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young
women, young men, older women, and older men using Magnetic Resonance (MR) imaging and
transcranial Doppler ultrasound (TCD). Data collection techniques will be compared.
vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young
women, young men, older women, and older men using Magnetic Resonance (MR) imaging and
transcranial Doppler ultrasound (TCD). Data collection techniques will be compared.
The investigators have recently shown that cerebral blood flow responses to chemical stimuli
are reduced in healthy older adults. The investigators also have preliminary data suggesting
that sex differences in cerebrovascular regulation exist. The overall goal of this
application is to extend on the investigators previous studies by employing advanced
neuroimaging techniques to enhance the investigators understanding of neurovascular coupling
in healthy aging. This study will collect clinically significant data with implications for
the future risk of cognitive decline and Alzheimer's disease.
The research aims are:
1. To determine the effect of age and sex on baseline cerebral blood flow through the
middle cerebral artery (MCA).
2. To determine the effect of age and sex on cerebral vasodilator responses.
3. To determine if the cerebrovascular responses measured by transcranial Doppler
ultrasound (TCD) are associated with the cerebrovascular responses measured by Magnetic
Resonance (MR) imaging.
are reduced in healthy older adults. The investigators also have preliminary data suggesting
that sex differences in cerebrovascular regulation exist. The overall goal of this
application is to extend on the investigators previous studies by employing advanced
neuroimaging techniques to enhance the investigators understanding of neurovascular coupling
in healthy aging. This study will collect clinically significant data with implications for
the future risk of cognitive decline and Alzheimer's disease.
The research aims are:
1. To determine the effect of age and sex on baseline cerebral blood flow through the
middle cerebral artery (MCA).
2. To determine the effect of age and sex on cerebral vasodilator responses.
3. To determine if the cerebrovascular responses measured by transcranial Doppler
ultrasound (TCD) are associated with the cerebrovascular responses measured by Magnetic
Resonance (MR) imaging.
Inclusion Criteria:
- Between 20-34 or 50-69 years
- Body mass index <34 kg/m2
Exclusion Criteria:
- Current smoker
- History or evidence of: hepatic disease, renal disease, hematological disease,
peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
- Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking
capacity to consent, etc.)
- Older females only: subject is not post-menopausal
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University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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