Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 50 - 79 |
| Updated: | 8/5/2018 |
| Start Date: | October 2016 |
| End Date: | December 2018 |
| Contact: | Nicholas A Burd, Ph.D. |
| Email: | naburd@illinois.edu |
| Phone: | 217-244-0970 |
Using stable isotope methodology, investigators will determine the postabsorptive and
postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: <30
kg/m2) immediately after an acute bout of resistance exercise. Participants will be divided
in to 5 groups of twelve women (n=12). Each group will receive a different protein beverage
or placebo to consume following the resistance exercise training. Group 1 will consume a
beverage consisting of whey protein; group 2 will consume whey protein supplemented with
additional leucine; group 3 will consume whey protein supplemented with additional leucine
and hydrolyzed whey peptides; group 4 will consume whey protein supplemented with additional
leucine and citrulline; group 5 will just consume water. During the testing, blood and muscle
samples will be collected.
postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: <30
kg/m2) immediately after an acute bout of resistance exercise. Participants will be divided
in to 5 groups of twelve women (n=12). Each group will receive a different protein beverage
or placebo to consume following the resistance exercise training. Group 1 will consume a
beverage consisting of whey protein; group 2 will consume whey protein supplemented with
additional leucine; group 3 will consume whey protein supplemented with additional leucine
and hydrolyzed whey peptides; group 4 will consume whey protein supplemented with additional
leucine and citrulline; group 5 will just consume water. During the testing, blood and muscle
samples will be collected.
Inclusion Criteria:
- BMI <30 kg/m2
- Healthy, sedentary
Exclusion Criteria:
- Tobacco use
- Allergies to milk consumption
- Unusually high protein consumption
- Vegan diet
- Allergies to antibiotics or xylocaine
- Phenylketonuria (PKU)
- Diagnosed GI tract diseases
- Arthritic conditions
- A history of neuromuscular problems
- Heart disease
- Metabolic disorders
- -Liver, kidney, or urinary disease
- Musculoskeletal problems
- Autoimmune disease
- Neurological disease
- Previous participation in amino acid tracer studies
- Predisposition to hypertrophic scarring or keloid formation
- Individuals on any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne
medications).
- Individuals using thyroid medications or other medications affecting endocrine
function
- Pregnancy
- Contraindications for exercise
- BMI ≥30
- supplements that influence protein metabolism (e.g omega 3 fish oils)
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