Neural Correlates of Cognition in Parkinson's Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 1/27/2019 |
| Start Date: | February 1, 2017 |
| End Date: | May 2020 |
| Contact: | Aysegul Gunduz, PhD |
| Email: | agunduz@bme.ufl.edu |
| Phone: | 352-273-6877 |
Cognitive impairment in Parkinson's disease (PD) has far-reaching effects on both motor
outcomes and quality of life in PD patients. Furthermore, deep brain stimulation (DBS), now
an evidence-based treatment for certain cases of PD, has the risk of causing deficits in
multiple areas of cognition.
As such, the purpose of this study is to understand the neuroanatomical and neurophysiologic
basis for impaired cognition in PD. The aim is to identify neural correlates of cognition by
measuring brain signal activity while PD patients are engaged in cognition on a computer.
outcomes and quality of life in PD patients. Furthermore, deep brain stimulation (DBS), now
an evidence-based treatment for certain cases of PD, has the risk of causing deficits in
multiple areas of cognition.
As such, the purpose of this study is to understand the neuroanatomical and neurophysiologic
basis for impaired cognition in PD. The aim is to identify neural correlates of cognition by
measuring brain signal activity while PD patients are engaged in cognition on a computer.
Study Participants: For this study, the investigators will recruit approximately 40 healthy
control participants and 40 Parkinson's disease (PD) patients that are undergoing deep brain
stimulation (DBS) as routine standard of care.
Screening: For healthy control participants, investigators will approach adults, aged 18-90,
for possible involvement in our study. Potential participants will be asked if they have ever
been diagnosed with a movement disorder, psychiatric disorder, or dementia. For PD patients
undergoing evaluation for DBS, investigators will first consult with their neurologist and
neurosurgeon. Next, investigators will approach the participant and explain the study.
Healthy Controls: Healthy controls will complete standardized questionnaires and play a
computer game to assess cognition, taking no longer than 30 minutes.
PD Participants: As part of the usual DBS process at University of Florida (UF), PD
participants will be asked to participate in this trial. There are three evaluation time
points: before surgery, during surgery, and possibly after surgery. Before surgery, the PD
patients will complete standardized questionnaires and be trained on a computer game to
assess cognition. During surgery, the participants will play the same computer game while
brain signals are recorded. When the patients return to University of Florida for DBS
programming visits within 48 months after surgery, they will repeat the standardized
questionnaires and computer game once again.
control participants and 40 Parkinson's disease (PD) patients that are undergoing deep brain
stimulation (DBS) as routine standard of care.
Screening: For healthy control participants, investigators will approach adults, aged 18-90,
for possible involvement in our study. Potential participants will be asked if they have ever
been diagnosed with a movement disorder, psychiatric disorder, or dementia. For PD patients
undergoing evaluation for DBS, investigators will first consult with their neurologist and
neurosurgeon. Next, investigators will approach the participant and explain the study.
Healthy Controls: Healthy controls will complete standardized questionnaires and play a
computer game to assess cognition, taking no longer than 30 minutes.
PD Participants: As part of the usual DBS process at University of Florida (UF), PD
participants will be asked to participate in this trial. There are three evaluation time
points: before surgery, during surgery, and possibly after surgery. Before surgery, the PD
patients will complete standardized questionnaires and be trained on a computer game to
assess cognition. During surgery, the participants will play the same computer game while
brain signals are recorded. When the patients return to University of Florida for DBS
programming visits within 48 months after surgery, they will repeat the standardized
questionnaires and computer game once again.
Controls:
- Inclusion criteria: Healthy adults between the ages of 18-90.
- Exclusion Criteria: Participants that have known movement disorders, psychiatric
disorders, or any type of dementia.
PD-DBS Participants:
- Inclusion Criteria: Persons undergoing DBS surgery for the implantation of electrodes
for the treatment of motor disorders
- Exclusion Criteria: Failure of the DBS surgical candidacy screening process
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