Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia



Status:Active, not recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:6 - 17
Updated:9/14/2018
Start Date:September 2014
End Date:December 31, 2020

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A randomized control trial examining the relationship between changes in hand function and
brain plasticity following intensive therapy. Two treatment approaches are used:
constraint-induced movement therapy (CIMT) or Hand-Arm Bimanual Intensive Therapy (HABIT).
The protocols have been developed at TC Columbia University to be child friendly and draw
upon our extensive experience with constraint-induced movement therapy in children with
cerebral palsy. Our center has been providing interventions camps for children with cerebral
palsy since 1998. The interventions are performed in a 15 day day-camp setting with several
children and at least one interventionist per child. The aim of the intervention is to
improve the use of the affected hand and quality of overall movement in a fun, social
setting. PARTICIPATION IS FREE. Please check out our website for more information:
http://www.tc.edu/centers/cit/

Constraint-induced Movement Therapy and Bimanual training are motor-learning based approaches
to engage children in fun activities. This study looks at what areas of the brain are
responsible for recovery after intensive training. We are trying to understand how the brain
responds to movement training and hope that in the future we can develop new treatments for
hemiplegia based on what we learn about the brain in this study.

To study the areas of the brain we will use Magnetic Resonance Imaging (MRI) to take pictures
of the brain and Transcranial Magnetic Stimulation (TMS) to determine parts of the brain
involved in using the hand. TMS uses a brief magnetic field over the scalp by using a wand
that looks like a figure 8. The wand can make brief magnetic fields over a series of spots on
your child's head to activate the brain cells under the wand. Non-invasive, single pulse TMS
will be used in this study, which is considered minimal risk and tolerable to children. If
your child has a recurrent history of seizures after two years of age, he/she might not
qualify.

Inclusion Criteria:

- Diagnosis of unilateral cerebral palsy

Exclusion Criteria:

- Current medical illness unrelated to CP

- Seizure disorder

- Current use of medications know to lower the seizure threshold

- Metallic object(s) in body, other than dental fillings

- Pregnancy

- Claustrophobia
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