INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

This research study is a Phase II clinical trial. Phase II clinical trials test the safety
and effectiveness of an investigational drug to learn whether the study drug works in
treating a specific disease. "Investigational" means that the drug is being studied.

In this research study, the investigators are looking to compare the effects, good and bad,
of the standard of care with the three investigational agent sub-studies Abemaciclib,
Neratinib, CC115 to help people with Glioblastoma including the specific molecular changes in
the genes and proteins.

The FDA has approved Temozolomide (temodar) as a treatment for this disease, however the FDA
has not approved Abemaciclib, CC115, Neratinib for any diseases.

Inclusion Criteria:

- Participants must have histologically confirmed intracranial glioblastoma or
gliosarcoma following maximum surgical resection. Tumors primarily localized in the
infratentorial compartment will be excluded.

- Participants may have had prior surgery for glioblastoma or gliosarcoma but no
systemic or radiation therapy.

- Age ≥ 18 years.

- Karnofsky performance status ≥60

- Participants must have normal organ and marrow function as defined below:

- Leukocytes ≥3,000/mL

- Absolute neutrophil count ≥1,500/mL

- Platelets ≥100,000/mL

- Hemoglobin ≥ 9g/dl

- Total bilirubin within normal institutional limits (except for participant's with
Gilbert's disease)

- AST(SGOT)/ALT(SGPT) ≤ 2.5 × institutional upper limit of normal

- Creatinine ≤ institutional upper limit of normal OR

- Creatinine clearance ≥ 60 mL/min/1.73 m2 for participants with creatinine levels
above institutional normal.

- Potassium within normal institutional range, or correctable with supplements

- Serum amylase ≤ 1.5 x institutional upper limit of normal

- Serum lipase ≤ 1.5 x institutional upper limit of normal

- INR < 2.0

- PTT ≤ institutional upper limit of normal, unless receiving therapeutic low
molecular weight heparin

- Must be able to swallow pills.

- Participants must plan to begin radiation therapy 14-42 days after surgical resection.

- Immunohistochemically negative for IDH1 R132H mutation.

- Evidence that the tumor MGMT promoter is unmethylated by standard of care assays.

- Genotyping data available or in process (data must be available at time of initial
registration if randomization probabilities differ across biomarker subgroups as
determined by the DFCI Coordinating Center) to assign biomarker subgroups through
whole exome sequencing, whole genome copy number analysis, or a combination as
described in Section 9.1.

- MRI with gadolinium should be obtained within 21 days prior to beginning treatment.
Patients without measurable disease are eligible. Participants must be able to undergo
MRIs (CTs are not allowed for response assessment on study).

- The effects of the experimental agents used in this study on the developing human
fetus are unknown. For this reason and because other therapeutic agents used in this
trial are known to be teratogenic, women of child-bearing potential (women who are not
free from menses for > 2 years, post hysterectomy/oophorectomy, or surgically
sterilized) and men must agree to use adequate contraception (hormonal or barrier
method of birth control; abstinence) prior to study entry and for the duration of
study participation unless otherwise specified in sub-study that the participant is
randomized to. Should a woman become pregnant or suspect she is pregnant while she or
her partner is participating in this study, she should inform her treating physician
immediately.

- For women of child bearing potential (women who are not free from menses for > 2
years, post hysterectomy/oophorectomy, or surgically sterilized) a negative serum
pregnancy test must be documented prior to initial registration.

- Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

- Participants will not be eligible if the original diagnosis was a lower grade glioma
and a subsequent histologic diagnosis revealed glioblastoma.

- Planned major surgery.

- Participants who are receiving any other investigational agents.

- Participants who have had any prior cranial radiotherapy.

- Planned use of Optune™.

- History of a different malignancy, unless (a) have been disease-free for at least 2
years and are deemed by the investigator to be at low risk for recurrence of that
malignancy, and/or (b) malignancy was cervical cancer in situ, superficial bladder
cancer or basal cell or squamous cell carcinoma of the skin, and malignancy has been
treated. Patients who meet the above listed criteria and are only on preventative
treatment will be deemed eligible.

- History of intratumoral or peritumoral hemorrhage if deemed significant by the
treating physician.

- Impaired cardiac function or clinically significant cardiac diseases, including any of
the following:

- Active uncontrolled cardiac disease, including cardiomyopathy, congestive heart
failure (New York Heart Association functional classification of ≥2), unstable angina,
myocardial infarction within 12 months of enrollment, or ventricular arrhythmia.

- Known history of congenital QT prolongation or Torsade de pointes (TdP).

- Complete left bundle branch or bifascicular block.

--QTc interval > 450 ms for men or > 470 ms for women.

- Persistent or history of clinically meaningful ventricular arrhythmias or atrial
fibrillation.

- Unstable pectoris or myocardial infarction ≤ 3 months prior to starting study
treatment.

- Uncontrolled hypertension (blood pressure ≥ 160/95 mmHg).

- Other clinically significant heart disease such as congestive heart failure requiring
treatment.

- Uncontrolled diabetes mellitus, or subjects with either of the following:

- Fasting blood glucose (FBG defined as fasting for at least 8 hours) ≥ 200 mg/dL (7.0
mmol/L), or

- HbA1c ≥ 8%

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, chronic liver disease (e.g., cirrhosis, hepatitis), chronic renal disease,
pancreatitis, chronic pulmonary disease, or psychiatric illness/social situations that
would limit compliance with study requirements. Subjects must be free of any
clinically relevant disease (other than glioma) that would, in the treating
investigator's opinion, interfere with the conduct of the study or study evaluations.

- Known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNS
[qualitative] is detected).

- Known acute or chronic pancreatitis.

- Participants with active diarrhea ≥ CTCAE grade 2 despite medical management.

- Active infection requiring antibiotics.

- Pregnant or breastfeeding.

- Impairment of gastrointestinal (GI) function or GI disease that may significantly
alter the absorption of study drug (e.g., ulcerative diseases, uncontrolled nausea,
vomiting, diarrhea, malabsorption syndrome, or extensive small bowel resection).
Participants with unresolved diarrhea ≥ CTCAE grade 2 will be excluded as previously
indicated.

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to any of the experimental agents or other agents used in study.

- Participants taking an enzyme-inducing anti-epileptic drug (EIAED): phenobarbital,
phenytoin, fosphenytoin, primidone, carbamazepine, oxcarbazepine, eslicarbazepine,
rufinamide, and felbamate. Participant must be off any EIAEDs for at least 7 days
prior to planned start of study treatment. A list of EIAED and other inducers of
CYP3A4 is provided. Among non-EIAED, caution is recommended with use of valproic acid
due to potential for drug interaction.

- Participants taking a drug known to be strong inhibitors or inducers of isoenzyme
CYP3A. Participant must be off CYP3A inhibitors and inducers for at least 7 days prior
to planned start of study treatment. NOTE: participants must avoid consumption of
Seville orange (and juice), grapefruit or grapefruit juice, grapefruit hybrids,
pummelos and exotic citrus fruits from 7 days prior to planned start of study
treatment and during the entire study treatment period due to potential CYP3A4
interaction.

- Current use of herbal preparations/medications, including but not limited to: St.
John's wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA),
yohimbe, saw palmetto, ginseng. Participants should stop using these herbal
medications 7 days prior to planned start of study treatment.

- Current use of warfarin sodium or any other coumadin-derivative anticoagulant.
Participant must be off Coumadin-derivative anticoagulants for at least 7 days prior
to planned start of study treatment. Low molecular weight heparin and factor Xa
inhibitors are allowed.