A Phase II Study of GSK1363089 (Formerly XL880) for Papillary Renal-Cell Carcinoma (PRC)



Status:Completed
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/13/2017
Start Date:June 30, 2006
End Date:August 18, 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase II Study of the c-MET RTK Inhibitor XL880 in Subjects With Papillary Renal-Cell Carcinoma

This clinical study is being conducted at multiple sites to determine the best confirmed
response rate, safety, and tolerability of GSK1363089 treatment in papillary renal cell
carcinoma. Papillary renal cell carcinoma may be classified into hereditary and sporadic
forms; subjects with either classification will be accepted into this study.


Inclusion Criteria:

- Histologically confirmed diagnosis of PRC with metastatic disease or bilateral
multifocal renal tumors localized to kidneys. Measurable disease, ECOG performance
status of
- Adequate bone marrow reserve, hepatic, renal, and cardiovascular function.

Exclusion Criteria:

- Radiation to >/=25% of bone marrow within 14 days of GSK1363089, more than 1 prior
anti-cancer therapy, received prior treatment with a c-met inhibitor, brain
metastases,

- Any uncontrolled intercurrent illness,

- Pregnant or breastfeeding,

- HIV positive
We found this trial at
12
sites
GSK Investigational Site
Indianapolis, Indiana 46202
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Indianapolis, IN
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GSK Investigational Site
Bethesda, Maryland 20892
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Bethesda, MD
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GSK Investigational Site
Boston, Massachusetts 02115
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Boston, MA
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GSK Investigational Site
Cleveland, Ohio 44195
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Cleveland, OH
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GSK Investigational Site
Detroit, Michigan 48202
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Detroit, MI
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GSK Investigational Site
Greenbrae, California 94904
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Greenbrae, CA
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GSK Investigational Site
Nashville, Tennessee 37203
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Nashville, TN
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GSK Investigational Site
New Brunswick, New Jersey 08901
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New Brunswick, NJ
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GSK Investigational Site
Philadelphia, Pennsylvania 19104
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Philadelphia, PA
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GSK Investigational Site
San Antonio, Texas 78258
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San Antonio, TX
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GSK Investigational Site
San Francisco, California 94115
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San Francisco, CA
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GSK Investigational Site
Stanford, California 94305
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Stanford, CA
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