An Investigational Immuno-therapy Study to Evaluate the Safety and Effectiveness of Experimental Medication BMS-986207 by Itself and in Combination With Nivolumab in Solid Cancers That Are Advanced or Have Spread
Status: | Recruiting |
---|---|
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 2/2/2019 |
Start Date: | November 29, 2016 |
End Date: | December 16, 2022 |
Contact: | Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email: |
Email: | Clinical.Trials@bms.com |
Phase 1/2a First-In-Human Study of BMS-986207 Monoclonal Antibody Alone and in Combination With Nivolumab in Advanced Solid Tumors
The purpose of this study is to evaluate the safety and effectiveness of experimental
medication BMS-986207 by itself and in combination with Nivolumab in solid cancers that are
advanced or have spread.
medication BMS-986207 by itself and in combination with Nivolumab in solid cancers that are
advanced or have spread.
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com
Inclusion Criteria:
- Women and men ≥18 years of age with Eastern Cooperative Oncology Group (ECOG)
performance status of 0 or 1
- Must have received and progressed on or failed one standard/approved treatment for
cancer type, if available
- At least 4 weeks since any previous treatment for cancer
- Subject must consent to pretreatment and on treatment tumor biopsies
- At least one lesion with measurable disease at baseline
- Adequate organ and marrow function
Exclusion Criteria:
- Patients with primary brain tumors or primary tumors with central nervous system
metastases as only location of disease. Controlled brain metastases are permitted
- Prior organ transplant
- Participants with second/other active cancers requiring current treatment
- Uncontrolled/significant heart disease
- History of chronic hepatitis, Positive test for Hepatitis B virus surface antigen or
Hepatitis C antibody (except participants with liver cancer) or Human Immunodeficiency
Virus/Acquired Immunodeficiency Syndrome(HIV/AIDS)
- Active/uncontrolled autoimmune disease
- Active infection
Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
7
sites
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92 2nd St
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 551-996-8598
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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