First in Patient Study for PF-06840003 in Malignant Gliomas

Inclusion Criteria:

- Diagnosis of WHO Grade IV glioblastoma or WHO Grade III anaplastic gliomas

- For patients with Grade IV GBM, recurrent disease at the time of the first or second
recurrence or progression. For patients with Grade III anaplastic gliomas, recurrent
disease at the time of at least a first recurrence but no more than a fourth
recurrence or progression

- Karnofsky performance score greater than or equal to 70%

- Adequate bone marrow, kidney and liver function

Exclusion Criteria:

- History of CNS bleeding within 6 months of registration

- Previous anti-angiogenics or anti-vascular endothelial growth factor within 12 months
of registration

- Requires treatment with high dose systemic corticosteroids defined as >2 mg/day

- Radiation therapy within 12 weeks of registration